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Abstract
Injudicious use of root canal medicaments can be one of the factors responsible for
posttreatment pain. Although many clinically effective drugs were reported as non-irritating,
very little controlled work was available to substantiate these claims. It seemed
desirable to know more about the properties of the drugs that we use and to couple
our knowledge of their antimicrobial potency with information regarding their inflammatory
potential.
In accordance with accepted medical and pharmaceutical methods, several nonspecific
root canal drugs and irrigants were tested by placement in the undifferentiated connective
tissue of rabbit integument and by deposition in rabbit eyes. One commonly used polyantibiotic
paste, distilled water, and a commonly used vehicle were also studied.
Many nonspecific root canal drugs were found to be highly irritating, as was the polyantibiotic
paste that was tested. Successful clinical use of these drugs does not prove them
to be less irritating but re-emphasizes the fact that drugs can and should be kept
from contacting periapical tissues. Commonly used irrigating solutions were found
to be slightly irritating but considerably less so than most drugs placed in the root
canals between visits. Zephiran chloride, distilled water, and cresatin exhibited
little or no inflammation potential. Some observations were made concerning the desirable
properties of cresatin.
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References
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Article info
Footnotes
☆This study was presented in partial fulfillment of the research requirements for the teaching research fellowship in endodontics at Temple University for the year 1955–1956. It represents work begun at Temple University and completed at Beth Israel Hospital in Boston.
☆This preliminary report was read at the annual session of the American Association of Endodontists in Chicago, Illinois, in February, 1957.
Identification
Copyright
© 1959 Published by Elsevier Inc.
