Research Article| Volume 12, ISSUE 2, P211-221, February 1959

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Inflammatory potential of root canal medicaments

A preliminary report including nonspecific drugs
  • Herbert Schilder
    Department of Stomatology, Boston University College of Medicine, Division of Endodontics, Boston, Mass., USA

    Department of Endodontics, Beth Israel Hospital, Boston, Mass., USA

    Post-Graduate Division, Temple University School of Dentistry, Philadelphia, Pa. USA

    Tufts University School of Dentistry, Boston, Mass., USA
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  • Morton Amsterdam
    the Department of Endodontics, Temple University School of Dentistry, Philadelphia, Pa. USA

    Graduate School of Medicine, University of Pennsylvania, Philadelphia, Pa. USA
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      Injudicious use of root canal medicaments can be one of the factors responsible for posttreatment pain. Although many clinically effective drugs were reported as non-irritating, very little controlled work was available to substantiate these claims. It seemed desirable to know more about the properties of the drugs that we use and to couple our knowledge of their antimicrobial potency with information regarding their inflammatory potential.
      In accordance with accepted medical and pharmaceutical methods, several nonspecific root canal drugs and irrigants were tested by placement in the undifferentiated connective tissue of rabbit integument and by deposition in rabbit eyes. One commonly used polyantibiotic paste, distilled water, and a commonly used vehicle were also studied.
      Many nonspecific root canal drugs were found to be highly irritating, as was the polyantibiotic paste that was tested. Successful clinical use of these drugs does not prove them to be less irritating but re-emphasizes the fact that drugs can and should be kept from contacting periapical tissues. Commonly used irrigating solutions were found to be slightly irritating but considerably less so than most drugs placed in the root canals between visits. Zephiran chloride, distilled water, and cresatin exhibited little or no inflammation potential. Some observations were made concerning the desirable properties of cresatin.
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