Research Article| Volume 12, ISSUE 5, P546-561, May 1959

Dental observations in Gaucher's disease

A twenty-year follow-up
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      Dental observations in eight cases of Gaucher's disease are described. In seven cases there were lesions in the mandible, the maxilla, and other parts of the skeletal system. One patient did not have any osseous dysplasia in the jaws when examined but did show changes in the femur.
      Two of the five cases that are described were followed for a period of twenty years.
      In one of these cases a biopsy of the mandible was performed to confirm the original presumptive diagnosis based on a biopsy from the humerus. The biopsy and diagnosis were confirmed by another observer.
      Both cases exhibited a slow, gradual enlargement of the original lesions observed in the early stages of the disease.
      Lesions manifested evidence of bone regeneration following surgical interference. This was later followed by a reappearance of loss of trabecular structure with a “worm-eaten” appearance of the mandible.
      One of the cases developed a spontaneous hemorrhage of the palatal mucosa.
      All the cases exhibited a loss of trabecular structure with a pseudocystic appearance in the molar and premolar areas of the mandible. A thinning of the bone cortex of the mandible was a constant finding. In the later stages of the disease, infiltrating Gaucher's cells can produce root resorption.
      Other intraoral x-ray changes, which have been confirmed by two cases reported in the literature, are described. Hemorrhagic complications following oral surgery are discussed. The dental findings in Gaucher's disease may have some diagnostic significance.
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        • Epstein E.
        • Lorenz K.
        Ztschr. f. physiol. Chem. 1930; 192: 145
        • Lieb H.
        Ztschr. f. physiol. Chem. 1924; 115: 305
        • Bender I.B.
        Dental Observations in Gaucher's Disease.
        J. D. Res. 1938; 17: 359
        • Tassman G.C.
        • Bender I.B.
        Gaucher's Disease: Case Report.
        J. Am. Dent. A. 1940; 27: 1268
        • Shira R.S.
        Manifestations of Systemic Disorders in the Facial Bones.
        J. Oral Surg. 1953; 11: 286
      1. Oral Surg., Oral Med. & Oral Path. 1953; 6: 1250
        • Spiegel Lewis H.
        Gaucher's Disease.
        Oral Surg., Oral Med. & Oral Path. 1957; 10: 158
        • Cahn L.R.
        Gaucher's Disease With Mandibular Bone Lesions.
        Oral Surg., Oral Med. & Oral Path. 1953; 6 (Comment on Moch): 1253