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Abstract
Dental observations in eight cases of Gaucher's disease are described. In seven cases
there were lesions in the mandible, the maxilla, and other parts of the skeletal system.
One patient did not have any osseous dysplasia in the jaws when examined but did show
changes in the femur.
Two of the five cases that are described were followed for a period of twenty years.
In one of these cases a biopsy of the mandible was performed to confirm the original
presumptive diagnosis based on a biopsy from the humerus. The biopsy and diagnosis
were confirmed by another observer.
Both cases exhibited a slow, gradual enlargement of the original lesions observed
in the early stages of the disease.
Lesions manifested evidence of bone regeneration following surgical interference.
This was later followed by a reappearance of loss of trabecular structure with a “worm-eaten”
appearance of the mandible.
One of the cases developed a spontaneous hemorrhage of the palatal mucosa.
All the cases exhibited a loss of trabecular structure with a pseudocystic appearance
in the molar and premolar areas of the mandible. A thinning of the bone cortex of
the mandible was a constant finding. In the later stages of the disease, infiltrating
Gaucher's cells can produce root resorption.
Other intraoral x-ray changes, which have been confirmed by two cases reported in
the literature, are described. Hemorrhagic complications following oral surgery are
discussed. The dental findings in Gaucher's disease may have some diagnostic significance.
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References
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- Gaucher's Disease With Mandibular Bone Lesions.Oral Surg., Oral Med. & Oral Path. 1953; 6 (Comment on Moch): 1253
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© 1959 Published by Elsevier Inc.
