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Research Article| Volume 12, ISSUE 3, P315-319, March 1959

Antibiotic levels in saliva obtained with a new antibiotic: Thiostrepton troche studies

DOI:https://doi.org/10.1016/0030-4220(59)90184-7
Antibiotic levels in saliva obtained with a new antibiotic: Thiostrepton troche studies
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      Abstract

      In order to study the saliva levels of a new antibiotic, Thiostrepton, which might be obtained following the administration of troches containing 10 mg. of this antibacterial substance, salivary specimens were assayed before, during, and after the administration of Thiostrepton troches to twelve adult male volunteer subjects. Our findings suggest that, in terms of the minimum inhibitory concentration of Thiostrepton against various susceptible microorganisms, saliva levels far in excess of this minimum inhibitory level are obtained during the period in which the troche is not yet completely dissolved and that the saliva Thiostrepton levels some thirty-five minutes after the troche had dissolved were also well in excess of the minimum inhibitory concentration in at least nine of the twelve subjects.
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      References

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        Thiostrepton, a New Antibiotic. I. In Vitro Studies.
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      4. Kutscher, A. H., Seguin, L., Rankow, R. M., and Piro, J. D.: Thiostrepton, a New Antibiotic; Disc Sensitivity Studies, Antibiotics & Chemotherapy. (In press.)

      5. Kelly, J., Schraft, W. C., Tuoti, F., and Kutscher, A. H.: Antibacterial Spectrum of a New Antibiotic, Thiostrepton; Disc Sensitivity Studies. (To be submitted for publication.)

      6. Kelly, J., Schraft, W., Kutscher, A. H., and Tuoti, F.: Thiostrepton, a New Antibiotic: Tube Dilution Sensitivity Studies. (To be submitted for publication.)

      7. Seguin, L., Kutscher, A. H., Zegarelli, E. V., Piro, J. D., and Rankow, R. M.: Antimicrobial Activity of Thiostrepton: Tube Dilution Studies. (To be submitted for publication.)

      8. Kutscher, A. H., Zegarelli, E. V., Rankow, R. M., Mercandante, J., and Piro, J. D.: Clinical Laboratory Studies on a New Topical Antibiotic: Thiostrepton. (To be submitted for publication.)

      Article info

      Footnotes

      ☆Thiostrepton troches for this study were supplied by the Squibb Institute for Medical Research, New Brunswick, New Jersey.

      Identification

      DOI: https://doi.org/10.1016/0030-4220(59)90184-7

      Copyright

      © 1959 Published by Elsevier Inc.

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