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Abstract
Thiostrepton, a new antibiotic, has been suggested as being highly active topically
but inactive in terms of systemic therapy when administered orally and ingested. Detailed
blood chemistry, hematology, and urine studies were undertaken in twenty-five patients
in order that any undesirable systemic effects on physiologic processes following
the topical oral administration of Thiostrepton in human beings might be observed.
Our findings indicate that no alteration in general body function and no untoward
reactions occurred as the result of the topical oral administration of approximately
1.43 grams per day of a 1 per cent Thiostrepton ointment in divided doses for a period
of one week.
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References
- Thiostrepton, a New Antibiotic. I. In Vitro Studies.in: Welch H. Martí-Ibañez F. Antibiotics Annual 1955–1956. Medical Encyclopedia, Inc, New York1956: 554
- Thiostrepton: a New Antibiotic. III. In Vivo Studies.in: Welch H. Martí-Ibañez F. Antibiotics Annual, 1955–1956. Medical Encyclopedia, Inc, New York1956: 562
- Thiostrepton, a New Antibiotic. II. Isolation and Chemical Characterization.in: Welch H. Martí-Ibañez F. Antibiotics Annual, 1955–1956. Medical Encyclopedia, Inc, New York1956: 560
- Thiostrepton, a New Antibiotic; Disc Sensitivity Studies.Antibiotics & Chemother. 1958; 8: 576
Article info
Publication history
With the Assistance of Ana Tiburcio
Footnotes
☆Thiostrepton ointment used in this study was supplied by the Squibb Institute for Medical Research, New Brunswick, New Jersey.
Identification
Copyright
© 1959 Published by Elsevier Inc.
