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Four original cases of spindle-cell squamous carcinoma of the lower lip are reported. Three of these cases were not associated with previous irradiation, thermal burn, or trauma. One was treated with an unknown liquid medication, and in this case there were several recurrences.
Clinically, all the lesions were less than 1 cm. in diameter and were of less than six months' duration. Histologically, all the lesions appeared well delineated; each showed surface ulceration and uniform spindle-cell structure.
In previously reported cases of spindle-cell carcinoma of the lip associated with irradiation, thermal burn, or trauma, prognosis was grave. In cases without a previous history of irradiation, thermal burn, or trauma, the prognosis appeared to be good.
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