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Research Article| Volume 12, ISSUE 11, P1285-1295, November 1959

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Giant-cell reparative granuloma and related conditions affecting the jawbones

  • L.Thomas Austin Jr.
    Affiliations
    From the Section of Dentistry and Oral Surgery, Mayo Foundation, Rochester, Minn., USA

    the Section of Surgical Pathology, Mayo Clinic and Mayo Foundation. Rochester, Minnesota, USA

    the Section of Dentistry, Mayo Clinic and Mayo Foundation. Rochester, Minnesota, USA The Mayo Foundation, Rochester, Minnesota, is a part of the Graduate School of the University of Minnesota.
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  • David C. Dahlin
    Affiliations
    From the Section of Dentistry and Oral Surgery, Mayo Foundation, Rochester, Minn., USA

    the Section of Surgical Pathology, Mayo Clinic and Mayo Foundation. Rochester, Minnesota, USA

    the Section of Dentistry, Mayo Clinic and Mayo Foundation. Rochester, Minnesota, USA The Mayo Foundation, Rochester, Minnesota, is a part of the Graduate School of the University of Minnesota.
    Search for articles by this author
  • R.Quentin Royer
    Affiliations
    From the Section of Dentistry and Oral Surgery, Mayo Foundation, Rochester, Minn., USA

    the Section of Surgical Pathology, Mayo Clinic and Mayo Foundation. Rochester, Minnesota, USA

    the Section of Dentistry, Mayo Clinic and Mayo Foundation. Rochester, Minnesota, USA The Mayo Foundation, Rochester, Minnesota, is a part of the Graduate School of the University of Minnesota.
    Search for articles by this author
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      Abstract

      In a study of benign multinucleated-cell-containing lesions of the jaws, sixty-four examples of giant-cell reparative granuloma and only two of genuine giant-cell tumor of bone were encountered at the Mayo Clinic in a fifty-two-year period. Other benign giant-cell-containing lesions, such as aneurysmal bone cysts, cherubism, fibrous dysplasia, and malignant tumors, must be distinguished from giant-cell reparative granuloma.
      The central and peripheral tumors of this giant-cell reparative process are so similar histopathologically that differentiation must be made on roentgenographic or surgical findings, and an arbitrary designation is sometimes necessary.
      Giant-cell reparative granulomas respond favorably to conservative surgical removal, which is the treatment of choice.
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