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A blind study on 210 office patients, selected at random, was undertaken to examine the relationship of the concentration of vasoconstrictor to the efficacy and duration of local anesthesia. Three concentrations of Neo-Cobefrin (1:15,000, 1:20,000, and 1:30,000) were used in combination with Ravocaine hydrochloride 0.4 per cent and Novocain 2 per cent. For purposes of comparison, the same anesthetic solution was also employed with Levophed and Cobefrin. Of the five solutions studied, the one containing Neo-Cobefrin 1:20,000 gave the highest incidence of completely satisfactory anesthesia, the shortest duration, and the lowest incidence of systemic reactions.
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© 1959 Published by Elsevier Inc.