Research Article| Volume 12, ISSUE 12, P1484-1495, December 1959

Structural cytology of the healing wound

I. The fibroblast
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      A morphologic study of the fibroblasts of a healing tooth extraction wound has been made by means of light microscopy and low-power electron microscopy. The knowledge gained with respect to the advanced fibroblast is confirmatory. The young fibroblast differs morphologically from the newly divided cell in normal connective tissue; there are characteristics indicative of primitive undifferentiated cells. Similarities were noticed between the young fibroblast of the healing wound and certain endothelial cells of associated capillaries. Extensive tubule systems within the cytoplasm of young fibroblasts formed spongelike networks. Such cellular networks are believed to hasten wound filling through expansion from within as cells surrounding the wound promote closure from without.
      Fibers were observed in a closer association with a cell type morphologically distinct from the classically depicted fibroblast. The proximity of the fibers to this “fibrocyte” necessitates a study of its role in fibrogenesis.
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