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The purpose of the present investigation was to determine the effect on the oral cavity of chronic visceral stimulation of the brain stem. Experiments were performed on seventeen dogs in which the stimulus was applied to two different procedures. Seven animals received traumatic irritation by means of a blunt probe. Ten animals were stimulated with glass beads located in the sella turcica which produced a mild continuous stimulation on the tuber cinereum, infundibulum, and mammillary bodies. Six animals served as controls and were operated upon in the same manner as the experimental animals but received no cerebral stimulation. All animals in the first group died by the eleventh postoperative day, showing severe hemorrhage of the gastric and intestinal mucosa and superficial erosion of the intestinal tract. No oral lesions were encountered. Six animals of the second group showed changes in the oral cavity. These changes were bleeding, ulcerous stomatitis, and periodontal disturbances. This latter group also exhibited gastric bleeding, focal lesions, and ulcers in the duodenum and jejunum. Control animals kept in the same environment showed no changes in either the oral cavity or the intestinal tract.
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☆This work was supported by Grants D-402 and D-741 of the National Institutes of Health, United States Public Health Service.
© 1959 Published by Elsevier Inc.