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Research Article| Volume 12, ISSUE 9, P1080-1089, September 1959

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A new vehicle (Orabase) for the application of drugs to the oral mucous membranes

  • Austin H. Kutscher
    Affiliations
    From the School of Dental and Oral Surgery, Columbia University, New York, N. Y. USA

    the Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, N. Y. USA

    the School of Public Health and Administrative Medicine of the Faculty of Medicine, Columbia University. New York, N. Y. USA
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  • Edward V. Zegarelli
    Affiliations
    From the School of Dental and Oral Surgery, Columbia University, New York, N. Y. USA

    the Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, N. Y. USA

    the School of Public Health and Administrative Medicine of the Faculty of Medicine, Columbia University. New York, N. Y. USA
    Search for articles by this author
  • Frank E. Beube
    Affiliations
    From the School of Dental and Oral Surgery, Columbia University, New York, N. Y. USA

    the Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, N. Y. USA

    the School of Public Health and Administrative Medicine of the Faculty of Medicine, Columbia University. New York, N. Y. USA
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  • Neal W. Chilton
    Affiliations
    From the School of Dental and Oral Surgery, Columbia University, New York, N. Y. USA

    the Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, N. Y. USA

    the School of Public Health and Administrative Medicine of the Faculty of Medicine, Columbia University. New York, N. Y. USA
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  • Charles Berman
    Affiliations
    From the School of Dental and Oral Surgery, Columbia University, New York, N. Y. USA

    the Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, N. Y. USA

    the School of Public Health and Administrative Medicine of the Faculty of Medicine, Columbia University. New York, N. Y. USA
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  • James L. Mercadante
    Affiliations
    From the School of Dental and Oral Surgery, Columbia University, New York, N. Y. USA

    the Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, N. Y. USA

    the School of Public Health and Administrative Medicine of the Faculty of Medicine, Columbia University. New York, N. Y. USA
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  • Irving B. Stern
    Affiliations
    From the School of Dental and Oral Surgery, Columbia University, New York, N. Y. USA

    the Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, N. Y. USA

    the School of Public Health and Administrative Medicine of the Faculty of Medicine, Columbia University. New York, N. Y. USA
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  • Norman Roland
    Affiliations
    From the School of Dental and Oral Surgery, Columbia University, New York, N. Y. USA

    the Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, N. Y. USA

    the School of Public Health and Administrative Medicine of the Faculty of Medicine, Columbia University. New York, N. Y. USA
    Search for articles by this author
DOI:https://doi.org/10.1016/0030-4220(59)90316-0
A new vehicle (Orabase) for the application of drugs to the oral mucous membranes
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      Abstract

      A new vehicle for the application of therapeutic agents to the oral mucous membranes is described. Various clinical tests were undertaken on a total of 119 patients (784 applications) in order to study the usefulness of this material as a vehicle for the prolonged application of medications to the oral mucous membranes.
      The findings indicate that when approximately 60 mg. (Group I), 250 mg. (Groups II and III), and 125 mg. (Group IV) of this vehicle adhesive are applied to various sites of the oral cavity, the average duration of maintenance was as follows: dorsum of the tongue—twenty-five, fifty-eight, and fifteen minutes for Groups I, II, and IV, respectively; hard palate—twenty-three, eighty-one, and thirty-three minutes for Groups I, II, and IV, respectively; anterior labial gingivae—twenty-four, 109, ninety-four, and fifty-six minutes for Groups I, II, and III, and IV; lower lingual anterior—eighty-five, sixty-four, and thirty-four minutes for Groups II, III, and IV; mucosa of the cheek—twenty-five, ninety-one, and forty-five minutes for Groups I, II, and IV; inner surface of the lower lip—103 minutes for Group II; and mucobuccal fold—152, and 108 minutes for Groups II and III, respectively.
      In no instance was there observed any evidence of irritation or other side reaction or toxicity, either local or systemic, due to the vehicle being studied.
      These data indicate a potential usefulness of this material as a vehicle for topical oral medications and mechanical protection in the oral cavity.
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      References

        • Rothner J.T.
        • Cobe H.M.
        • Rosenthal S.L.
        • Bailin J.
        An Adhesive Penicillin Ointment for Topical Application.
        J. D. Res. 1949; 28: 544

      2. Roland, N., Kutscher, A. H., Zegarelli, E. V., Chilton, N. W., and Mercadante, J.: Mucohesive, a New Long-Lasting Vehicle for the Application of Drugs to the Oral Mucous Membranes. II. (Submitted for publication.)

      Article info

      Publication history

      With the Assistance of Ferdinand Tuoti, D.M.D., John D. Piro, D.D.S., Jack Budowsky, D.D.S., Robert Herlands, D.D.S., Robin M. Rankow, D.D.S., M.D., and Herbert F. Silvers, D.D.S.

      Footnotes

      ☆The adhesive vehicle used in this study is available from E. R. Squibb & Sons as Orabase and was supplied by The Squibb Institute for Medical Research, New Brunswick, New Jersey. It contains gelatin, pectin, carboxymethyl cellulose, and Plastibase.

      ☆Portions of this study were carried out by members of the William Jarvie Society for Dental Research (School of Dental and Oral Surgery, Columbia University), whose cooperation is gratefully acknowledged herewith: F. Berlin, A. Dell, M. W. Diamond, A. E. DiCerbo, R. Dubner, M. K. Gellis, W. A. Gutstein, E. Herzig, D. E. Hopp, N. Kahn, E. Katz, I. J. Lelling, K. D. Levin, R. Lifschutz, M. G. Mage, S. Merl, M. P. Merritt, S. M. Murphy, N. R. Napoli, S. S. Osleeb, A. C. Palermo, M. C. Rennert, J. Rosen, M. Ross, R. Rothman, L. I. Slawin, C. S. Solomon, T. Spier, S. M. Steinerman, and G. H. Stoller.

      Identification

      DOI: https://doi.org/10.1016/0030-4220(59)90316-0

      Copyright

      © 1959 Published by Elsevier Inc.

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