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Research Article| Volume 14, ISSUE 4, P442-453, April 1961

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A histochemical study of the keratotic process in oral lesions diagnosed clinically as leukoplakia

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      Abstract

      The keratotic process was studied microscopically and histochemically in eighty oral lesions diagnosed clinically as leukoplakia. In all lesions the stratum corneum was thickened and presented varied degrees of hyperkeratosis or parakeratosis, separately or in combination. Several histochemical differences between the hyperkeratotic and parakeratotic lesions were noted. Of particular interest was the observation that hyperkeratotic lesions were characterized by an increase in disulfides and a diminution in sulfhydryls in the stratum corneum which did not occur in parakeratotic lesions. An intermittent type of keratosis was also described.
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      References

        • Van Scott E.J.
        • Flesch P.
        Sulfhydryl Groups and Disulfide Linkages in Normal and Pathological Keratinization.
        A. M. A. Arch. Dermat. & Syph. 1954; 70: 141
        • Barrnett R.J.
        • Seligman A.M.
        Histochemical Demonstration of Sulfhydryl and Disulfide Groups of Protein.
        J. Nat. Cancer Inst. 1954; 14: 769
        • Giroud A.
        • Leblond C.P.
        The Keratinization of Epidermis and Its Derivatives, Especially the Hair as Shown by X-Ray Diffraction and Histochemical Studies.
        Ann. New York Acad. Sc. 1951; 53: 613-626
        • Barron E.S.G.
        Thiol Groups of Biological Importance.
        Rec. Advances Enzymol. 1951; 11: 201
        • Steiner K.
        A Histochemical Study of Epidermal Glycogen in Skin Diseases.
        J. Invest. Dermat. 1955; 24: 599
        • Lustig B.
        • Katchen B.
        • Reiss F.
        The Amino Acid Composition of the Horny Layer of the Human Skin.
        J. Invest. Dermat. 1958; 30: 159
        • Matoltsy A.G.
        • Balsamo C.A.
        A Study of the Components of the Cornified Epithelium of Human Skin.
        J. Biophys. & Biochem. Cytol. 1955; 4: 339
        • Matoltsy A.G.
        Keratinization of Embryonic Skin.
        J. Invest. Dermat. 1958; 3: 343
        • Rothman S.
        Physiology and Biochemistry of the Skin.
        University of Chicago Press, Chicago1954
        • Turesky S.
        • Crowley J.
        • Glickman I.
        A Histochemical Study of Protein-Bound Sulfhydryl and Disulfide Groups in Normal and Inflamed Human Gingiva.
        J. D. Res. 1957; 36: 255
        • Turesky S.
        • Glickman I.
        • Fisher B.
        The Effect of Physiologic and Pathologic Processes Upon Certain Histochemically Detectable Substances in the Gingiva.
        J. Periodontol. 1959; 30: 116
        • Turesky S.
        • Glickman I.
        • Litwin T.
        A Histochemical Evaluation of Normal and Inflamed Human Gingiva.
        J. D. Res. 1951; 30: 792
        • Dewar M.R.
        Observations on the Composition and Metabolism of Normal and Inflamed Human Gingivac.
        J. Periodontol. 1955; 26: 29
        • Renstrup Grete
        Leukoplakia of the Oral Cavity.
        Acta odont. scandinav. 1958; 16: 99