Research Article| Volume 14, ISSUE 4, P442-453, April 1961

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A histochemical study of the keratotic process in oral lesions diagnosed clinically as leukoplakia

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      The keratotic process was studied microscopically and histochemically in eighty oral lesions diagnosed clinically as leukoplakia. In all lesions the stratum corneum was thickened and presented varied degrees of hyperkeratosis or parakeratosis, separately or in combination. Several histochemical differences between the hyperkeratotic and parakeratotic lesions were noted. Of particular interest was the observation that hyperkeratotic lesions were characterized by an increase in disulfides and a diminution in sulfhydryls in the stratum corneum which did not occur in parakeratotic lesions. An intermittent type of keratosis was also described.
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