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The role of the accessory epidermal structures, sebaceous glands and hair follicles, in skin carcinogenesis has been reviewed and a comparison made between the response of epidermal and oral mucous membrane epithelium to the action of carcinogenic hydrocarbons. The rather marked susceptibility to tumor induction of an oral epithelium which is devoid of accessory structures has been pointed out. In light of this finding, as well as the reports of other investigators,1, 2 it is suggested that epithelial adnexa acting as requisites to chemical induction of tumors may merit some re-evaluation.
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☆The experimental studies described in this report were supported by grants from the United States Public Health Service and the Damon Runyon Memorial Fund for Cancer Research.
© 1961 Published by Elsevier Inc.