Research Article| Volume 21, ISSUE 6, P764-769, June 1966

Download started.


Enzyme histochemistry of human oral carcinoma

      This paper is only available as a PDF. To read, Please Download here.


      Histochemical techniques for the determination of lactic dehydrogenase activity and succinic dehydrogenase activity were applied to the study of ten cases of epidermoid carcinoma of oral mucosa. A notable increase in lactic dehydrogenase activity was found, as well as a decrease in succinic dehydrogenase activity, when oral carcinoma was compared with normal oral mucosa.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


        • Kabat E.A.
        • Furth J.
        A Histochemical Study of the Distribution of Alkaline Phosphatase in Various Normal and Neoplastic Tissues.
        Am. J. Path. 1941; 17: 303
        • Greenstein J.P.
        Esterase Activity of Normal and Neoplastic Tissues of the Mouse.
        J. Nat. Cancer Inst. 1944; 51: 31
        • Reiner L.R.
        • Rutenburg A.M.
        • Seligman A.M.
        Acid Phosphatase Activity in Human Neoplasms.
        Cancer. 1957; 10: 563
        • Monis B.
        • Rutenburg A.M.
        Alkaline Phosphatase Activity in Neoplastic and Inflammatory Tissues of Man.
        Cancer. 1960; 13: 538
        • Cohen R.B.
        • Nachlas M.M.
        • Seligman A.M.
        Histochemical Demonstration of Esterase in Malignant Tumors.
        Cancer Res. 1951; 11: 709
        • Lemon H.M.
        • Davison M.M.
        • Asimov I.
        Acid Phosphatase Activity of Normal and Neoplastic Human Tissues.
        Cancer. 1954; 7: 92
        • Monis B.
        • Weinberg T.
        Cytochemical Study of Esterase Activity of Human Neoplasms and Stromal Macrophages.
        Cancer. 1961; 14: 369
        • Gomori G.
        Distribution of Acid Phosphatase in the Tissues Under Normal and Under Pathological Conditions.
        Arch. Path. 1941; 32: 189
        • Santis H.
        • Shklar G.
        A Histochemical Study of Human Oral Carcinoma.
        Oral Surg., Oral Med. & Oral Path. 1964; 17: 84
        • Santis H.
        • Shklar G.
        • Chauncey H.H.
        Histochemistry of Experimentally Induced Leukoplakia and Carcinoma of the Hamster Buccal Pouch.
        Oral Surg., Oral Med. & Oral Path. 1964; 17: 207
        • Shklar G.
        Metabolic Characteristics of Experimental Hamster Pouch Carcinomas.
        Oral Surg., Oral Med. & Oral Path. 1965; 20: 336
        • Cataldo E.
        • Shklar G.
        • Chauncey H.H.
        Experimental Submaxillary Gland Tumors in Rats; Histology and Histochemistry.
        Arch. Path. 1964; 77: 305
        • Ogata T.
        • Mori M.
        Histochemical Study of Oxidative Enzymes in Vertebrate Muscle.
        J. Histochem. 1964; 12: 171
        • Morrison J.H.
        • Kronheim S.
        Cytochemical Demonstration of Succinie Dehydrogenase in Mouse Leukocytes.
        J. Histochem. 1962; 10: 402
        • Monis B.
        • Nachlas M.M.
        • Seligman A.M.
        Histochemical Study of Three Dehydrogenase Systems in Human Tumors.
        Cancer. 1959; 12: 1238
        • Warburg O.
        On the Origin of Cancer Cells.
        Science. 1956; 123: 309
        • Shklar G.
        Lactic Dehydrogenase Activity in Cytologic Smears of Normal Oral Mucosa and Epidermoid Carcinoma.
        Acta cytol. 1965; 9: 437