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Research Article| Volume 21, ISSUE 2, P143-147, February 1966

The effect of certain hemostatic agents and the local use of diluted epinephrine on bleeding during oral surgical procedures

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      Abstract

      The volume of blood lost by 125 patients during full-mouth extractions and alveoloplasty under general anesthesia was measured.
      The patients were placed into five groups of twenty-five patients each. One group was used as a control and did not receive a special hemostatic agent; another received 2 per cent lidocaine with 1:100,000 epinephrine; the other three groups received Koagamin, Kutapressin, and Premarin, respectively. The latter three hemostatic agents were given preoperatively according to the manufacturers' instructions.
      The vasoconstrictive effect of the epinephrine in the local anesthetic greatly decreased the average blood loss, whereas the other hemostatic agents had no effect. The control patients bled an average of 282 ml.; the lidocaine and epinephrine group, 189 ml.; the Koagamin group, 315 ml.; the Kutapressin group, 296 ml.; and the Premarin group, 276 ml.
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      References

        • Johnson R.L.
        Blood Loss in Oral Surgery.
        J. D. Res. 1956; 35: 175-184
        • Johnson J.F.
        An Estrogenic Preparation and Certain Coagulation Factors (Abst.).
        J. Michigan M. Soc. 1957; 56: 1444
        • Schiff Maurice
        • Burn Helen F.
        The Effect of Intravenous Estrogens on Ground Substance.
        Arch. Otolaryng. 1961; 73: 43-51
        • Nathanson N.R.
        Control of Bleeding With Premarin Intravenous in Oral Surgery.
        Oral Surg., Oral Med. & Oral Path. 1961; 14: 397-400
        • Steinberg Arthur
        • Brown W.R.
        A New Concept Regarding the Mechanism of Clotting and the Control of Hemorrhage.
        Am. J. Physiol. 1939; 126: 638
        • Schumann E.A.
        Newer Concepts of Blood Coagulation and the Control of Hemorrhage.
        Am. J. Obst. & Gynec. 1939; 38: 1002-1005
        • Lynch R.L.
        The Effect of Koagamin on the Coagulation Time.
        Chron. Omaha Dist. D. Soc. 1963; 26: 211-215
        • Marshall Wallace
        • Kozelka A.W.
        • Kuljis Dominic
        Hemorrhage: Control During and Following Tonsillectomies and Adenoidectomies.
        M. Times. 1955; 83: 563-566
        • Holtman D.E.
        The Use of a New Vasoconstrictor (Kutapressin) in Exodontia: A Clinical Study.
        Oral Surg., Oral Med. & Oral Path. 1954; 7: 12-20
        • Harris S.C.
        • North W.C.
        • North A.B.
        The Influence of Kutapressin on the Human Bleeding and Clotting Times.
        Oral Surg., Oral Med. & Oral Path. 1954; 7: 239-240
        • Crawford O.B.
        • Hallock G.V.
        • Truant A.P.
        • Wilder A.S.
        Kylocaine.
        in: Astra Pharmaceutical Products, Inc Chemistry, Pharmacology and Clinical Applications, Worcester, Massachusetts. 1960: 9-73
        • Gores R.J.
        • Royer R.Q.
        • Mann F.D.
        Blood Loss During Operation for Multiple Extraction With Alveoloplasty and Other Oral Surgical Procedures.
        J. Oral Surg. 1955; 13: 299-306
        • Pilcher Jr., Frederick
        • Sheard Charles
        Measurements on the Loss of Blood During Transurethral Prostatic Resection and Other Surgical Procedures, Determined by Spectrophotometric and Photelometric Methods.
        in: ed. 4. Proc. Staff Meet., Mayo Clin. 12. 1937: 209-213
        • Wilcox III, C.F.
        • Hunt A.E.
        • Owen Jr., C.A.
        The Measurement of Blood Lost During Cesarean Section.
        Am. J. Obst. & Gynec. 1959; 77: 772-779
        • Cooner W.H.
        • Burros H.M.
        Clinical Evaluation of Effect of Premarin on Bleeding During and Following Prostatic Surgery.
        J. Urol. 1960; 83: 64-66
        • Thajeb Sjarif
        • Kurkcuoglu Muzaffer
        • McElfresh A.E.
        The Value of Systemic Hemostatic Drugs: A “Double Blind” Evaluation of Agents Used to Increase Coagulation During Tonsillectomy and Adenoidectomy.
        Arch. Otolaryng. 1959; 70: 72-74