Research Article| Volume 21, ISSUE 2, P143-147, February 1966

The effect of certain hemostatic agents and the local use of diluted epinephrine on bleeding during oral surgical procedures

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      The volume of blood lost by 125 patients during full-mouth extractions and alveoloplasty under general anesthesia was measured.
      The patients were placed into five groups of twenty-five patients each. One group was used as a control and did not receive a special hemostatic agent; another received 2 per cent lidocaine with 1:100,000 epinephrine; the other three groups received Koagamin, Kutapressin, and Premarin, respectively. The latter three hemostatic agents were given preoperatively according to the manufacturers' instructions.
      The vasoconstrictive effect of the epinephrine in the local anesthetic greatly decreased the average blood loss, whereas the other hemostatic agents had no effect. The control patients bled an average of 282 ml.; the lidocaine and epinephrine group, 189 ml.; the Koagamin group, 315 ml.; the Kutapressin group, 296 ml.; and the Premarin group, 276 ml.
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