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- 1.1. Subcutaneous transplants of the enamel-forming epithelium of the rat grew out first as cords and later as nests of epithelial cells.
- 2.2. A continuous production of P.A.S.-positive material separated the epithelial cords from the surrounding stroma in the early transplants. This represented attempted enamel matrix formation later when the cells formed tubular structures.
- 3.3. No enamel was formed. Foci of calcification unrelated to the epithelial proliferations represented a protective mechanism.
- 4.4. Comparison with ameloblasts previously grown in tissue culture emphasizes that these cells can revert to a less specialized epithelium, regardless of their previous activity. Epithelial proliferations, as in ameloblastomas, can probably arise from any part of the enamel-forming epithelium.
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☆This work was supported by Grant C-06215 from the National Cancer Institute, National Institute of Health, United States Public Health Service.
© 1966 Published by Elsevier Inc.