Research Article| Volume 21, ISSUE 2, P217-224, February 1966

Download started.


Transplantation of the enamel-forming epithelium

      This paper is only available as a PDF. To read, Please Download here.


      • 1.
        1. Subcutaneous transplants of the enamel-forming epithelium of the rat grew out first as cords and later as nests of epithelial cells.
      • 2.
        2. A continuous production of P.A.S.-positive material separated the epithelial cords from the surrounding stroma in the early transplants. This represented attempted enamel matrix formation later when the cells formed tubular structures.
      • 3.
        3. No enamel was formed. Foci of calcification unrelated to the epithelial proliferations represented a protective mechanism.
      • 4.
        4. Comparison with ameloblasts previously grown in tissue culture emphasizes that these cells can revert to a less specialized epithelium, regardless of their previous activity. Epithelial proliferations, as in ameloblastomas, can probably arise from any part of the enamel-forming epithelium.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


        • Zussman W.V.
        • Ioachim H.L.
        Growth of Ameloblasts In Vitro. II. Dental Tissue Culture Studies.
        Lab. Invest. 1964; 13: 887
        • Zussman W.V.
        • Ioachim H.L.
        Growth of Odontoblasts In Vitro. I. Dental Tissue Culture Studies.
        Lab. Invest. 1964; 13: 371
        • Marsland E.A.
        Histological Investigation of Amelogenesis in Rats. Part I. Matrix Formation.
        Brit. D. J. 1951; 91: 251
        • Marsland E.A.
        Histological Investigation of Amelogenesis in Rats. Part II. Maturation.
        Brit. D. J. 1952; 92: 109
        • Reith E.J.
        The Ultrastructure of Ameloblasts During Matrix Formation and the Maturation of Enamel.
        J. Biophys. & Biochem. Cytol. 1961; 9: 825
        • Hunt A.M.
        • Paynter K.J.
        The Role of Cells of the Stratum Intermedium in the Development of the Guinea Pig Molar; a Study of Cell Differentiation and Migration Using Tritiated Thymidine.
        Arch. Oral Biol. 1963; 8: 65
        • Reith E.J.
        The Enamel Organ of the Rat's Incisor; Its Histology and Pigment.
        Anat. Rec. 1959; 133: 75
        • Pearse A.G.E.
        Histochemistry, Theoretical and Applied.
        in: ed. 2. Little, Brown & Co, Boston1960: 831
        • Zegarelli E.V.
        Adamantoblastomas in the Slye Stock of Mice.
        Am. J. Path. 1944; 20: 23
        • Baden E.
        Contribution à l'étude de l'améloblastome du maxillaire inférieur.
        Rev. mensuelle suisse odonto-stomatol. 1964; 74: 1
        • Villa V.G.
        Calcification of the Epithelial Rests and Portion of the Reduced Enamel Epithelium in the Tooth Follicle of an Embedded Molar.
        Oral Surg., Oral Med. & Oral Path. 1951; 4: 877
        • Von Rijssel T.G.
        • Mühlbock O.
        Intramandibular Tumors in Mice.
        J. Nat. Cancer Inst. 1955; 16: 659
        • Hollander C.F.
        • Von Rijssel T.G.
        Experimental Production of Intramandibular Carcinoma in Mice by Mechanical Damage.
        J. Nat. Cancer Inst. 1963; 30: 337
        • Thoma K.
        • Goldman H.M.
        Oral Pathology.
        ed. 5. The C. V. Mosby Company, St. Louis1960
        • Gorlin R.J.
        • Chaudhry A.P.
        • Pindborg J.J.
        Odontogenic Tumors, Classification, Histopathology, and Clinical Behavior in Man and Domesticated Animals.
        Cancer. 1961; 14: 73
      1. Zussman, W. V.: Osteogenic Activity of Odontoblasts in Transplanted Tooth Pulps, J. D. Res. In press.