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Abstract
The histologic response of periapical tissues to root canal fillings with zinc oxide-eugenol
cement was studied in the lower molars of rats.
Root canal fillings were placed in normal teeth of 141 Wistar rats, and the animals
were killed at different postoperative periods ranging from 24 hours to 90 days. Semiserial
sections of each specimen were made, and, on the basis of the reported findings, the
following conclusions may be drawn:
Zinc oxide-eugenol cement showed satisfactory properties of plasticity and dimensional
stability, but it did not prove its adhesiveness to the root canal walls. It showed
no signs of solubility or permeability to body fluids within the postoperative periods
of this investigation.
Whenever this material set in a dense mass, it showed a marked resistance to resorption.
Zinc oxide-engenol cement was found to be highly irritating to the periapical tissues
and caused necrosis of bone and cementum when it came in contact with them. Polymorphonuclear
leukocytic infiltration was seen in the periodontal ligament and persisted for 2 weeks
or more.
On the other hand, when the body tissue encapsulated the zinc oxide-eugenol with a
fibrous capsule, an area of loose connective tissue with cell infiltration could be
seen, as a rule, between the zinc oxide-eugenol cement and the fibrous capsule.
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References
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Article info
Footnotes
☆This study was supported by a grant (02290-01) from the National Institute of Dental Research, United States Public Health Service.
Identification
Copyright
© 1967 Published by Elsevier Inc.
