Research Article| Volume 24, ISSUE 6, P808-816, December 1967

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Development of oral lesions in erythema multiforme exudativum

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      The development of oral lesions in erythema multiforme exudativum has been divided into five distinct stages—macular, bullous, sloughing, pseudo-membranous, and healing. Each stage is clinically and histologically different and is dependent upon the degree of lesion development. Evidence has been presented to suggest an intraepithelial rather than an intradermal origin of the oral bulla of erythema multiforme exudativum. Each stage has been illustrated by clinical photographs and demonstrated microscopically to show the progress of the lesions from initial eruption to final healing. Knowledge of this progression should aid both in diagnosis and in the prediction of the approximate length of time the patient will have the disease.
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