Research Article| Volume 24, ISSUE 6, P837-841, December 1967

Von Willebrand's disease

Report of a case
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      A case of Von Willebrand's disease has been presented. This familial disorder of great variability is characterized by prolonged bleeding time and a deficiency of a coagulation factor. A careful history is important in helping to determine the presence of a bleeding disorder. Repeated bleeding time determinations (Ivy method) and tourniquet tests are recommended for any patient whose history is suggestive of a bleeding disorder. An assay of Factor VIII is necessary before a diagnosis of Von Willebrand's disease can be made.
      Surgical procedures can be carried out safely if fresh frozen plasma is given preoperatively and immediately postoperatively. Continued transfusions usually are not required.
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        • Wintrobe Maxwell M.
        Clinical Hematology.
        in: ed. 5. Lea & Febiger, Philadelphia1961: 289
        • Von Willebrand E.A.
        Hereditar Pseudohemofili.
        Finska läk.-sällsk. handl. 1926; 68: 87
        • Wake Eric J.
        • McClure Peter D.
        Von Willebrand's Disease: Entity or Syndrome.
        New York J. Med. 1965; 65: 2783
        • Alexander B.
        • Goldstein R.
        Dual Hemostatic Defect in Pseudohemophilia.
        J. Clin. Invest. 1953; 32: 551
        • Sjolin K.E.
        • Videback A.
        Christmas Factor Deficiency and Decreased Capillary Resistance in a Female With Hemorrhagic Diathesis.
        Danish M. Bull. 1956; 3: 85
        • Salzman E.V.
        • Britten A.
        Hemorrhage and Thrombosis.
        in: Little, Brown & Co, Boston1965: 61-62
        • Borchgrevink C.F.
        Platelet Adhesion In Vivo in Patients With Bleeding Disorders.
        Acta med. scandinav. 1961; 162: 361
        • Salzman E.V.
        Measurement of Platelet Adhesiveness: Simple In Vitro Technique Demonstrating Abnormality in Von Willebrand's Disease.
        J. Lab. & Clin. Med. 1963; 62: 724
        • Zucker M.B.
        In Vitro Abnormality of Blood in Von Willebrand's Disease Correctable by Normal Plasma.
        Nature (London). 1963; 197: 601
        • Gaarder A.
        • Jonsen J.
        • Laland S.
        • Hellem A.
        • Owren P.A.
        Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood Platelets.
        Nature (London). 1961; 192: 531
        • Nilsson I.M.
        • Blomback M.
        • Blomback B.
        Von Willebrand's Disease in Sweden; Its Pathogenesis and Treatment.
        Acta med. scandinav. 1959; 164: 263
        • Douglas B.L.
        Pseudohemophilia: Report of a Case.
        J. Oral Surg. 1958; 16: 77-79
      1. Ann. Dent. 1944; 2: 152
        • Solomon H.
        • Tatarski I.
        Von Willebrand's Disease in Two Families.
        Israel J. M. Sc. 1965; 1: 866-869