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The dental pulps of germ-free and conventional Sprague-Dawley rats were surgically exposed and treated with corticosteroid and obtundent drugs and were either sealed by means of a temporary cement or left exposed to the oral environment. The results showed that, regardless of medication or closure, the pulps of conventional animals degenerated, whereas the pulps of germ-free animals healed uneventfully as substantiated by the formation of a reparative dentine bridge. The application of the steroid formula immediately following pulpal exposure was neither helpful nor harmful.
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© 1969 Published by Elsevier Inc.