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Abstract
An outbreak of hand-foot-and-mouth disease among students and staff members of a dental
hospital is described. Coxsackie virus A, type 16, was isolated from the saliva of
two patients but only after concentration procedures had been used. A probable explanation
for this finding is offered.
The clinical features are compared with those of some previous outbreaks, and the
oral lesions in particular are contrasted with those found in herpes simplex stomatitis.
The two conditions may be confused when clinical criteria alone are available.
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© 1969 Published by Elsevier Inc.