Research Article| Volume 48, ISSUE 4, P292-297, October 1979

Investigation of the vascular effect of newer local anesthetics and vasoconstrictors

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      Changes in blood flow can be measured with the aid of infrared thermography and make possible a comparative assessment of the vascular effect of vasoconstrictors and local anesthetics. With Adrenalin, vasoconstriction sets in immediately following infiltration; with POR-8,
      Sandoz AG, Basel, Switzerland.
      Sandoz AG, Basel, Switzerland.
      a sufficient vasoconstriction is observed only after 10 to 15 minutes. In both products, ischemia subsides after 60 minutes. Adrenalin then reverses the reaction in reactive hyperemia after 150 minutes, while the tissue infiltrated with POR-i returns to normal after 120 minutes. When combining a local anesthetic with a vasoconstrictor, the intrinsic vascular effect has to be considered. We experimentally proved that Novocain (procaine), Hostacain (butanilicaine), and on a lower scale Xylocaine (lignocaine) have a vasodilator effect. Citanest (prilocaine) demonstrates no vasodilatory effect. Carbocaine (mepivacaine) produces a mild vasoconstriction.
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      1. Anker, J.: Personal communications, 1978.

        • Evers H.
        Zur Problematik der gefäβkonstrahierenden Zusätze bei der örtlichen Betäubung.
        Therapiewoche. 1966; 47: 1586
        • Ganssen A.
        Medizinische Thermographie.
        Röntgenpraxis. 1974; 24: 24
        • Hensel J.
        • Priebe L.
        Fluviographie-Thermische Durchblutungsmessung.
        Acta Mediotechnica. 1970; 18: 74
        • Hensel J.
        • Langemock B.
        Effect of local anaesthetics on oral blood flow in human subjects.
        in: Emmelin and Zotterman: Oral Physiology. 1972: 157 (Oxford-New York)
        • Klammt J.
        Die Durchführung der Lokalanästhesie beim gefährdeten Patienten.
        Dtsch. Stomat. 1972; 22: 110
        • Klingenström P.
        • Nylen B.
        • Westermark L.
        Experimental and clinical investigations of the local vasoconstrictive effect of two derivatives of pituitary posterior lobe hormones.
        Plast. Reconstr. Surg. 1967; 39: 503
        • Lindorf H.H.
        • Ganssen A.
        • Popp M.
        Thermographic observation of the vascular behaviour in response to local anaesthetics and pressor agents.
        in: First European Congress on Thermography, Amsterdam1974
        • Lindorf H.H.
        Experimentelle Untersuchung der vaskulären Wirkung von Adreanlin- und POR-8 Infiltration im Kiefer-bereich.
        Schweiz. Mschr. Zahnheilk. 1975; 85: 536
        • Luduena F.P.
        Duration of local anaesthesia.
        Ann. Rev. Pharmacol. 1969; 91: 503
        • Marlette R.H.
        Anaesthetic management of the cardiac patient in oral surgery.
        Oral Surg. 1964; 18: 600
        • Mathes H.
        • Andree G.
        • Neumann R.
        Klinische Beobachtungen bei der Anwendung eines neuen Vasokonstriktors: Ornithin-Vasopressin (POR-8).
        Prakt. Anästh. Wiederbeleb. 1969; 4: 132
        • Nolte H.
        • Dudeck J.
        • Dudeck Th.
        • Hützwohl B.
        Ornithin-Vasopressin (POR-8) als Vasokonstringens in der regionalen Anästhesie.
        Anaesthesis. 1972; 21: 398
        • Petersen J.K.
        • Lück J.
        • Kristensen F.
        • Mikkelsen L.
        A comparison of four commonly used local analgesics.
        Int. J. Oral Surg. 1977; 6: 51
        • Steinhäuser E.W.
        Zahnärztlich-chirurgische Eingriffe bei Patienten mit Störungen der Blutgerinnung.
        Dtsch. Zahnärztl. Z. 1974; 29: 650