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Research Article| Volume 48, ISSUE 6, P517-522, December 1979

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The induction of hyperkeratotic white lesions in hamster cheek pouches with mouthwash

  • Mark L. Bernstein
    Correspondence
    Reprint requests to: Dr. Mark L. Bernstein School of Dentistry University of Louisville Health Sciences Center Louisville, Ky. 40232
    Footnotes
    Affiliations
    Department of Oral Pathology/Pathology, School of Dentistry, University of Louisville Health Sciences Center Louisville, Ky., USA
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  • Robert Carlish
    Footnotes
    Affiliations
    Department of Oral Pathology/Pathology, School of Dentistry, University of Louisville Health Sciences Center Louisville, Ky., USA
    Search for articles by this author
  • Author Footnotes
    ∗ Associate Professor, Department of Oral Pathology/Pathology.
    ∗∗ Resident, Department of Periodontics, School of Dentistry, University of North Carolina, Chapel Hill, N. C.
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      Abstract

      Listerine mouthwash applied to the left cheek pouch mucosa of thirty-seven hamsters 45 minutes daily for 41 days caused diffuse, corrugated white lesions showing hyperkeratosis in 100 percent of the animals. The right (control) side showed essentially no changes in response to saline solution applied similarly. The significance of these findings is discussed.
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