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Abstract
An objective evaluation of 55 patients with chronic vesiculoerosive oral diseases
was made to compare the beneficial and adverse effects of prednisone treatment. Patients
were divided into groups of high, intermediate, and low drug dosages, as well as short
and long periods of administration. Prednisone benefited 49 patients in spite of the
fact that 55% had some adverse side effects. The duration of prednisone administration
appeared to have a larger impact on side effects than the daily amount given. The
most common side effects were gastrointestinal disturbances, mood alterations, polyuria
and insomnia. There were no significant changes in blood pressure, blood sugar level,
weight, or white blood cell counts. This study confirmed that systemic prednisone
is a useful and beneficial treatment modality for patients with chronic oral inflammatory
diseases.
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References
- Steroid-induced fractures and bone loss in patients with asthma.N Engl J Med. 1983; 309: 265-268
- Adverse side effects associated with prednisone in the treatment of patients with oral inflammatory ulcerative diseases.J Am Dent Assoc. 1984; 109: 269-270
- Prednisone and azathioprine in the treatment of oral inflammatory disease.Oral Surg Oral Med Oral Pathol. 1981; 52: 257-260
- Pemphigus vulgaris: a study of six cases treated with levamisole and prednisone.Oral Surg Oral Med Oral Pathol. 1982; 54: 161-165
- Association of adrenocorticosteroid therapy and peptic ulcer disease.N Engl J Med. 1983; 309: 21-24
- Adrenocorticoid therapy and peptic ulcer disease.N Engl J Med. 1984; 310: 201-212
- Endogenous hydrocortisone, a possible factor contributing to the genesis of cushingoid habitus in patients on prednisone.J Clin Endocrinol Metab. 1981; 5: 1076-1080
- Prednisolone pharmacodynamics assessed by inhibition of the mixed lymphocyte reaction.Transplantation. 1982; 33: 578-584
- Prednisolone clearance: a possible determinant for glucocorticoid efficacy in patients with oral vesiculoerosive diseases.J Dent Res. 1983; 62: 575-577
- Administration of prednisolone in vivo affects the ratio of OKT4/OKT8 and LDH-isoenzyme pattern of human T lymphocytes.Clin Immunol Immunopathol. 1984; 30: 91-103
Article info
Footnotes
☆This study was partially supported by Grant DE 05890-01 from the National Institute of Dental Research, National Institutes of Health.
Identification
Copyright
© 1985 Published by Elsevier Inc.
