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Research Article| Volume 59, ISSUE 4, P364-370, April 1985

HLA-A, B, C, DR, MT, and MB antigens in recurrent aphthous stomatitis

  • Giuseppe Gallina
    Correspondence
    Reprint requests to: Dr. Giuseppe Gallina Istituto di Odontostomatologia Università di Palermo Policlinico—via del Vespro 90127 Palermo, Italy
    Affiliations
    Institute of Clinical Dentistry, University of Palermo Palermo, Italy

    Institute of General Pathology, University of Palermo Palermo, Italy
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  • Vincenzo Cumbo
    Affiliations
    Institute of Clinical Dentistry, University of Palermo Palermo, Italy

    Institute of General Pathology, University of Palermo Palermo, Italy
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  • Pietro Messina
    Affiliations
    Institute of Clinical Dentistry, University of Palermo Palermo, Italy

    Institute of General Pathology, University of Palermo Palermo, Italy
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  • Calogero Caruso
    Affiliations
    Institute of Clinical Dentistry, University of Palermo Palermo, Italy

    Institute of General Pathology, University of Palermo Palermo, Italy
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      Abstract

      In this report we have investigated the frequencies of HLA-A, B, C, DR, MT, and MB markers in 26 Silician subjects affected by recurrent aphthous stomatitis (RAS) and in 84 healthy controls. Our data show that the frequency of HLA-DR7 antigen is significantly increased in RAS-affected persons (61.5% versus 21.4%; pc < 0.0025), whereas the B5 antigen frequency is decreased significantly (absent in patients versus 27.3% in controls; pc = 0.04). Thus, present results suggest that HLA-linked genetic factors may play a role in the development of RAS.
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