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Abstract
In this report we have investigated the frequencies of HLA-A, B, C, DR, MT, and MB
markers in 26 Silician subjects affected by recurrent aphthous stomatitis (RAS) and
in 84 healthy controls. Our data show that the frequency of HLA-DR7 antigen is significantly
increased in RAS-affected persons (61.5% versus 21.4%; pc < 0.0025), whereas the B5
antigen frequency is decreased significantly (absent in patients versus 27.3% in controls;
pc = 0.04). Thus, present results suggest that HLA-linked genetic factors may play
a role in the development of RAS.
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Article info
Footnotes
☆This work was supported by a grant of “Ministero della Pubblica Istruzione,” Rome, to Prof. C. Caruso (40% 1982, 1983).
Identification
Copyright
© 1985 Published by Elsevier Inc.