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Abstract
The analgesic effectiveness of meclofenamate sodium (Meclomen)
†Meclomen (meclofenamate sodium), a product of Parke-Davis, Division of Warner-Lambert,
Morris Plains, N. J.
at two dose levels, 200 mg and 100 mg, was compared with the effectiveness of a placebo
and aspirin, 600 mg, in a double-blind study of 174 adult outpatients who had undergone
removal of impacted third molars. When compared with the placebo, meclofenamate sodium
at either dose level produced a significantly greater reduction in pain intensity,
greater pain relief, fewer withdrawals for inefficacy, greater percentage of patients
who considered their medication effective, and greater percentage of patients considered
by the investigator to have received drug-attributable benefits. In comparison with
aspirin, 600 mg, meclofenamate sodium at either 200 mg or 100 mg produced significantly
greater reduction in pain intensity and greater pain relief. The other measures of
efficacy showed no significant differences between the two drugs. Side effects were
minimal in all treatment groups. Meclofenamate sodium appears to be a safe and effective
analgesic for the control of pain.To read this article in full you will need to make a payment
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© 1985 Published by Elsevier Inc.
