This paper is only available as a PDF. To read, Please Download here.
Abstract
The clinicopathologic characteristics of orofacial aspergillosis in thirteen hospitalized
patients who developed the infection while receiving chemotherapy for acute leukemia
are described. Clinically, the primary sites of infection, in decreasing order of
frequency, were the paranasal sinuses, nasal cavity, mouth, and facial skin; the corresponding
order for the secondary sites was orbit, nasal cavity, facial skin, and mouth. Pathologically,
the fungal lesions in the nasal, oral and sinusoidal cavities were black, ulcerated,
and escharotic due as a direct result of tissue destruction by the organism and an
indirect result of thrombotic vascular infarction. The orbital lesions were deep red,
granulomatous, and productive of proptosis and ectropion. Seven of the thirteen patients
had concomitant pulmonary aspergillosis. The orofacial infections were not responsive
to antifungal therapy in the absence of remission of the leukemia and restoration
of depressed host defenses. In two patients who did achieve remission, the aspergillosis
was controlled by the intravenous administration of amphotericin B.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Aspergillus infection in cancer patients.JAMA. 1976; 235: 411-412
- Infection in patients with cancer.in: Holland JF Frei III, E Cancer medicine. ed. 2. Lea & Febiger, Philadelphia1982: 1339-1372
- Aspergillosis complicating neoplastic disease.Am J Med. 1973; 54: 6-15
- Aspergillosis in a cancer hospital.Cancer. 1964; 17: 747-756
- Tissue reactions to Aspergillus in cases of Hodgkin's disease and leukemia.J Clin Pathol. 1960; 13: 396-413
- Aspergillosis of the frontal sinus.Arch Otolaryngol. 1978; 104: 153-156
- Aspergillosis of the nose and paranasal sinuses.Laryngoscope. 1982; 92: 764-766
- Aspergillosis of the paranasal sinuses.Am J Otolaryngol. 1979; 1: 6-14
- Endogenous Aspergillus endophthalmitis occurring after kidney transplant.Am J Ophthalmol. 1975; 79: 502-509
- Aspergillosis.Medicine. 1970; 49: 147-173
- Catalogue of Strains. I. ed. 15. American Type Culture Collection, Rockville, Md1982
- Aspergillus species.in: Mandell GL Douglas Jr, RG Bennett JE Principles and practice of infectious diseases. John Wiley & Sons, New York1979: 2002-2008
- Phycomycosis complicating leukemia and lymphoma.Ann Intern Med. 1972; 78: 871-879
- Fulminant aspergillosis of the nose and paranasal sinuses: a new clinical entity.Laryngoscope. 1980; 90: 748-754
Article info
Identification
Copyright
© 1985 Published by Elsevier Inc.
