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Abstract
Localization of hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBcAg)
in the human parotid gland and liver was studied by an immunohistochemical method
in four cases with seropositive HBsAg. Neither HBsAg nor HBcAg could be detected in
the parenchymal cells of the parotid gland in any of the cases. However, one of four
cases, which had the highest titer of serum HBsAg, showed HBsAg immunoreactivity in
the vascular wall and luminal fluid of the parotid gland. In liver, HBsAg was detected
in three and HBcAg in two of the four cases, respectively. HBsAg was localized in
the cytopiasm of hepatocytes, while HBcAg was localized mainly in their nuclei. The
detection of HBsAg in the parotid gland and liver was correlated with the serum titer
of the antigen. The results indicate that the HB virus does not have an affinity for
or a replicate in the parotid gland. Also, it is suggested that the HBsAg found in
saliva is derived from HBsAg circulating through the oral mucosa by capillary leakage
and not from secretion into the mouth by the salivary gland.
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© 1985 Published by Elsevier Inc.
