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Abstract
Sera from subjects with recurrent aphthous ulceration (RAU) and control subjects were
tested for relative levels of IgM, IgG, and IgA antibodies against eight selected
laboratory-maintained bacteria, including Streptococcus sanguis which has been implicated in the etiopathogenesis of RAU. There were no differences
in relative serum antibody levels for any isotype against any bacteria between control
and RAU groups. RAU subjects with active lesions were then paired with control subjects,
and each serum was tested against sedimentable material derived from the oral mucosa
of each pair member. The analysis of data indicated that RAU and control subjects
had similar levels of serum antibodies to indigenous mucosal antigens, but RAU subjects
had significantly less antigenic material than control subjects.
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Article info
Footnotes
☆This investigation was supported by United States Public Health Service Grant RR05304, awarded by the Biomedical Research Support Grant Program, National Institute of Dental Research, National Institutes of Health.
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Copyright
© 1985 Published by Elsevier Inc.