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Abstract
Patients with cystic fibrosis (CF) are often hosts to colonies of both mucoid and
nonmucoid strains of Pseudomonas aeruginosa. The major pathogens for chronic and recurrent pulmonary infection in these patients
are the mucoid variants of P. aeruginosa. Of the 31 CF patients studied, 14 patients yielded both mucoid and nonmucoid strains
of P. aeruginosa from the various oral ecologic sites and saliva. Of the sites tested, the dorsum
of the tongue gave the highest yield of P. aeruginosa (27 strains), followed by the buccal mucosa (17 strains), saliva (15 strains), and
dental plaques (6 strains). Eleven patients had P. aeruginosa in the oral cavity and sputum simultaneously. Antibiotic susceptibility tests on
these multiple isolates suggest that CF patients may be cocolonized or coinfected
by two or more strains of P. aeruginosa. Therefore, it may be important to identify multiple isolates of P. aeruginosa, not only from sputum cultures but also from oral cultures, for antibiotic-susceptibility
testing. Oral colonization by the mucoid variants of P. aeruginosa may lead to further colonization in the lower respiratory tract and subsequent pulmonary
infection in CF patients.
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Article info
Footnotes
☆This investigation was supported by a grant from the Medical Research Council of Canada to the College of Dentistry, University of Saskatchewan.
Identification
Copyright
© 1985 Published by Elsevier Inc.
