This paper is only available as a PDF. To read, Please Download here.
Abstract
Oral administration of 0.001% 4NQO in drinking water resulted in a high incidence
of tongue carcinoma in rats. In other major organs, tumor induction was rarely observed.
The most frequent site of tongue carcinoma was the dorsum. No metastases were found.
Changes observed included carcinoma in situ and invasive carcinoma. Carcinoma in situ
showed erosion, leukoplakia, and a gross papillary appearance. Histologically, most
carcinomas in situ showed full-thickness alteration of epithelium. Some carcinomas
in situ in papillary lesions showed slightly less than full-thickness alteration of
epithelium, exhibiting downward, well-differentiated growth. Invasive carcinomas were
either endophytic or exophytic. Histologic grading of invasive carcinoma varied from
highly to poorly differentiated. The method described offers a new experimental animal
model of tongue carcinoma.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Experimentelle Studien über die Entstehung des Zungenkrebses.Mitt Med Akad Kioto. 1935; 15: 861-880
- The experimental production of carcinoma of the tongue in mice.J Dent Res. 1958; 37: 950
- Experimental production of labial and lingual carcinoma by local application of 4-nitroquinoline N-oxide.J Natl Cancer Inst. 1965; 35: 907-918
- Experimental production of carcinoma of the hamster tongue.J Dent Res. 1967; 46: 148
- Experimental production of lingual carcinoma by local application of 4-nitroquinoline 1-oxide.J Jpn Stomatol Soc. 1969; 18 (in Japanese): 609-624
- Experimental production of lingual carcinoma in hamsters by local application of 9, 10-dymethyl-1,2 benzanthracene.J Dent Res. 1973; 52: 327-332
- Carcinogenesis in the esophagus: experimental production of esophageal cancer by administration of ethanolic solution of carcinogens.Gann. 1965; 56: 429-441
- Organotrope carcinogen Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an B-D-Ratten.Z Krebsforsch. 1967; 69: 103-201
- Tumors of the upper digestive tract of ACI/N rats given N-propyl-N-nitrosoure-than in the drinking water.Gann. 1967; 67: 549-559
- Induction of squamous cell carcinoma in the oral cavity of rats by oral administration of 4-nitroquinoline 1-oxide (4NQO) in the drinking water.Bull Tokyo Dent Coll. 1983; 22: 85-93
- Verrucous carcinoma.Int Dent J. 1972; 22: 451-459
- A study of experimental production of tongue carcinoma.J Jpn Stomatol Soc. 1972; 21 (in Japanese): 999-1010
- Experimental production of lingual leukoplakia and carcinoma.Oral Surg Oral Med Oral Pathol. 1977; 44: 578-586
- Hamster tongue carcinogenesis. I. Characteristics of the experimental model.J Oral Pathol. 1981; 10: 322-331
- Verrucous carcinoma of the oral cavity.Surgery. 1948; 23: 670-678
- Experimental production of lingual carcinoma in hamster: tumor characteristics and site of formation.J Dent Res. 1973; 52: 1176-1185
Article info
Footnotes
☆This study was supported in part by a grand-in-aid from the Ministry of Education, Science and Culture of Japan (58771463).
Identification
Copyright
© 1985 Published by Elsevier Inc.
