Research Article| Volume 59, ISSUE 6, P627-636, June 1985

Effects of vitamin E dietary supplements on the exposed dental pulp in rats

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      Forty adult male Sprague-Dawley rats were divided into two equal groups, control (Group 1) and experimental (Group 2). Group 2 received 100 mg of dl-alpha-tocopherol acetate (vitamin E) twice weekly by the oral route. After 2 weeks the animals in both groups were subjected to pulp exposures that were capped with zinc oxide and eugenol and to pulp exposures that were left open. The oral administration of 100 mg dl-alpha-tocopherol acetate in the Group 2 animals was continued for periods of 1 day to 4 weeks after the operative procedures. The animals were killed 1 day, 3 days, and 1, 2, and 4 weeks after the procedures. The most severe, prolonged, and extensive pulpal disease was seen in both groups when the pulp exposure was left open to the oral flora. The most favorable repair and healing results took place after 1,2, and 4 weeks in the Group 2 animals in pulp exposures covered with zinc oxide and eugenol.
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        • Kamimura M
        Antiinflammatory activity of vitamin E.
        J Vitaminol. 1972; 18: 204-209
        • Heinzerling RH
        • Tengerdy RP
        • Wick LL
        • Leuker D
        Vitamin E protects mice against Diplococcus pneumoniae Type 1 infection.
        Infect Immun. 1974; 10: 1292-1295
        • Heinzerling RH
        • Nockels CF
        • Quarles CL
        • Tengerdy RP
        Proection of chicks against E. coli infection by dietary supplementation with vitamin E.
        in: Proc Soc Exp Biol Med. 146. 1974: 279-287
        • Tengerdy RP
        • Brown JC
        Effects of vitamin E and A on homoral immunity and phagocytosis in E. coli infected chickens.
        Poult Sci. 1977; 56: 957-963
        • Likoff RO
        • Guptill DR
        • Lawrence LM
        • McKay CC
        • Mathias MM
        • Nockels CF
        • Tengerdy RP
        Vitamin E and aspirin depress prostaglandins in protection of chickens against Escherichia coli infection.
        Am J Clin Nutr. 1981; 34: 245-251
        • Tengerdy RP
        • Heinzerling RH
        • Nockels CF
        Effects of vitamin E on the immune response of hypoxic and normal chickens.
        Infect Immun. 1972; 5: 987-989
        • Tengerdy RP
        • Heinzerling RH
        • Browns GL
        • Mathias MM
        Enhancement of the humoral immune response by vitamin E.
        Int Arch Allergy Appl Immunol. 1973; 44: 211-232
        • Shelly BE
        • Schultz R
        Influence of vitamin E and selenium on immune response mechanisms.
        in: Fed Proc. 38. 1979: 2139-2143
        • Tanaka JH
        • Fujinara H
        • Torisce M
        Vitamin E and immune response. I. Enhancement of helper T cell activity by dietary supplementation of vitamin E in mice.
        Immunology. 1979; 38: 727-734
        • Kim JE
        • Shklar G
        The effect of vitamin E on the healing of gingival wounds in rats.
        J Periodontol. 1982; 54: 305-308
        • Calandriello M
        • Capuzzi P
        • Martani F
        • Stefanini F
        Ricerche sperimental: Sull impiego della Vitamina E (a-tocopherol) sul processo di cicatrizzatione della ferita post-extractiva.
        Riv Ital Stomatol. 1967; 22: 743-771
        • Sveen OB
        • Hawes RR
        Differentiation of new odontoblasts and dentin bridge formation in rat molar teeth after tooth grinding.
        Arch Oral Biol. 1968; 13: 1399-1412
        • Seltzer S
        • Bender IB
        • Kaufman IJ
        Histologic changes in dental pulp of dogs and monkeys following application of pressure, drugs, and microorganisms or prepared cavities. Part I and Part II.
        Oral Surg Oral Med Oral Pathol. 1961; 14: 327-346
        • Seltzer S
        • Bender IB
        • Kaufman IJ
        Histologic changes in dental pulp of dogs and monkeys following application of pressure, drugs, and microorganisms or prepared cavities. Part I and Part II.
        Oral Surg Oral Med Oral Pathol. 1961; 14: 856-867
        • Martinek RG
        Method for determination of vitamin E (total tocopherols) in serum.
        Clin Chem. 1964; 10: 1078-1086
        • Kakehashi S
        • Stanley HR
        • Fitzgerald RJ
        The effects of surgical exposures of dental pulp in germ-free and conventional laboratory rats.
        Oral Surg Oral Med Oral Pathol. 1965; 20: 340-349
        • Paterson RC
        Bacterial contamination and the exposed pulp.
        Br Dent J. 1976; 140: 231-236
        • Alam SQ
        • Alam BS
        • Alvarez CJ
        Cariogenic effects of excess vitamin E in rats.
        J Dent Res. 1978; 57: 244
        • Hogg ME
        Radioimmunoassay of prostaglandins in pulpal and periapical inflammation.
        in: Thesis. Boston University, 1977
        • Gallo-Torres HG
        Transport and metabolism of vitamin E. VI. Excretion.
        in: Machlin LJ Vitamin E: A comprehensive treatise. Marcel Dekker, Inc, New York1980: 250
        • Obersztyn A
        Healing of pinpoint exposure of rat incisor pulp under various capping agents.
        J Dent Res. 1966; 45: 1130-1143
        • Mjor IA
        • Tronstad L
        The healing of experimentally induced pulpitis.
        Oral Surg Oral Med Oral Pathol. 1974; 38: 115-121