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Abstract
Gingival overgrowth, dental plaque, and gingivitis were assessed by means of standardized
semiquantitative indices in thirty renal transplant patients undergoing immunosuppression
with cyclosporin-A (Cy-A). Radioimmunoassay techniques were used to determine Cy-A
in serum samples and in parotid, submandibular, and whole saliva samples from each
patient. A significant positive correlation was found between gingival overgrowth
scores and both dental plaque and gingivitis scores. A significant positive correlation
was found between whole-saliva Cy-A and both plaque and gingival overgrowth scores.
No such correlation was found when parotid Cy-A or submandibular Cy-A was considered.
This was attributed to differences in saliva-collection methods, and a possible role
of dental plaque as a local reservoir of Cy-A is proposed.
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References
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© 1987 Published by Elsevier Inc.
