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Abstract
Thirty-eight biopsy specimens were examined for involucrin reactivity by an immunoperoxidase
technique. The sampling consisted of specimens diagnosed as normal oral mucosa, reactive
epithelial hyperplasia, lichen planus (LP), nonspecific lichenoid stomatitis (NLS),
lichenoid dysplasia (LD), carcinoma in situ, and squamous cell carcinoma (SCCa) on
routine hematoxylin and eosin examination. Findings were consistent with prior observations
of involucrin reactivity in skin and cervical-vaginal mucosa. Specifically, conditions
characterized by predominance of mature squamous epithelial cells (superficial layers
of normal and hyperplastic oral epithelium, NLS, and LP) exhibited strong involucrin
reactivity in such areas. In contrast, atypical or dysplastic lichenoid lesions (LD),
as well as carcinoma in situ, despite squamoid differentiation, demonstrated irregular
distribution of involucrin, suggesting disturbances in terminal differentiation. Invasive
components of SCCa revealed markedly diminished involucrin expression. These findings
support prior evidence that LP and LD are biologically distinct lesions. Clinically
and microscopically, both may be morphologically similar. However, involucrin reactivity
should be helpful in distinguishing difficult cases. Accordingly, we suggest that
the use of involucrin immunoreactivity may prove to be a valuable adjunct in the separation
of similar lichenoid oral conditions.
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© 1987 Published by Elsevier Inc.
