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The maxillary molar pulps of germ-free rats were mechanically exposed, and suspensions of a strain of freshly grown Streptococcus mutans were applied to the pulp wounds. The pulps were left open to the oral environment, and the animals were maintained in the isolator until they were killed in groups after 2, 7, and 28 days. After 2 days there was little evidence of any pulp response. In the 7-day group early pulp necrosis was present. No evidence of inflammatory infiltration was delected in either the 2- or 7-day animals. After 28 days there was extensive pulp necrosis in many specimens. Dentine bridges were present in fewer than one fourth of the teeth.
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☆The experimental work described in this article formed part of the M.D.S. thesis submitted by Prof. Paterson to the University of London.
© 1987 Published by Elsevier Inc.