This paper is only available as a PDF. To read, Please Download here.
Abstract
Monoclonal antibodies were used in histopathologic and immunohistologic studies of
periapical granulomas. In cellular zones, plasma cells and lymphocytes predominated,
with variable numbers of fibroblasts, macrophages, and polymorphonuclear leukocytes.
Labeling with monoclonal antibodies disclosed relatively infrequent, usually scattered
macrophages. Plasma cells were numerous and frequently clumped. The vast majority
of lymphocytes were T cells, scattered individually or in small groups of three or
four cells and dispersed throughout the granulomas without any topographic predilection,
with prevalence of T-suppressor/cytotoxic cells over T-helper/inducer cells. Our findings
of numerous plasma cells, which were in agreement with descriptions of numerous immunoglobulin-producing
cells by other authors, imply the participation of antibody-mediated immune reactions
in periapical granulomas. The presence of cell-mediated immunity, in spite of numerous
T cells, could not be confirmed.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Immunopathogenesis of chronic periapical lesions.Oral Surg Oral Med Oral Pathol. 1978; 46: 658-699
- Experimental study on focal infection in rabbits by prolonged sensitization through dental pulp canals.Arch Oral Biol. 1967; 12: 1017-1034
- Pathologic study of periapical lesions. 1. Periapical granulomas: clinical, histologic and immunohistopathologic studies.J Oral Pathol. 1980; 9: 288-300
- Antibody-producing cells in human periapical granulomas and cysts.J Endod. 1981; 7: 447-452
- Deposits of immunoglobulins and complement factor C3 in human dental periapical inflammatory lesions.Scand J Dent Res. 1983; 91: 191-199
- In situ characterization of cell infiltrates in human dental periapical granulomas. 1. Demonstration of receptors for the Fc region of IgG.J Oral Pathol. 1982; 11: 47-57
- Scanning electron microscopy of cells from periapical lesions.J Endod. 1975; 1: 291-294
- Isolation and characterization of inflammatory cells from the human periapical granuloma.J Dent Res. 1982; 61: 1408-1412
- Cellular immune response of patients with periapical pathosis to necrotic dental pulp antigens determined by release of LIF.J Endod. 1978; 4: 282-287
- Quantitative analysis of cellular composition of human periapical granuloma.J Endod. 1981; 7: 117-122
- Characterization of the periapical surgical specimen: a morphologic and histochemical study of the inflammatory patterns.Oral Surg Oral Med Oral Pathol. 1982; 53: 293-302
- Immunreaktion als Ursache einer nekrotisierenden epitheliodzelligen Endzündung ?.Dtsch Zahnärztl Z. 1979; 36: 38-41
- Regulation of the immune response—inducer and suppressor T-lymphocyte subsets in human beings.N Engl J Med. 1980; 301: 1018-1022
- Immunoregulatory T cell subpopulations in man: dissection by monoclonal antibodies and Fc receptors.Immunol Rev. 1983; 74: 5-28
- Delayed hypersensitivity.in: 2nd ed. Frontiers of biology. Vol. 4. Elsevier-North Holland Publishing Company, Amsterdam1967: 46
- Delayed Cellular Hypersensitivity.in: Movat HZ Inflammation, immunity and hypersensitivity: Cellular and Molecular Mechanisms. 2nd ed. Medical Department, Harper & Row, New York1979: 271
- Immunohistological analysis of delayed-type hypersensitivity in man.Cell Immunol. 1982; 74: 358-369
- Experimental gingivitis in humans: a histochemical and immunological characterization of the lymphoid cell subpopulations.J Periodont Res. 1983; 18: 375-385
- Morphology of delayed-type hypersensitivity reaction in man. II. Ultrastructural alterations affecting the microvasculature and the tissue mast cells.Lab Invest. 1976; 34: 179-191
- Delayed-type hypersensitivity: activation of mast cells by antigen-specific T-cell factors initiates the cascade of cellular interactions.Immunol Today. 1983; 4: 259-264
- Cell biology of mast cells and basophils.in: ed. 11. Handbook of inflammation, Vol. 2. The cell biology of inflammation. Elsevier/North-Holland Biomedical Press, Amsterdam1980: 217
- Clarification of the terms granulomatous and granulation tissue.J Oral Pathol. 1981; 10: 307-310
- A histopathologic, histobacteriologic and radiographic study of periapical endodontic surgical specimens.Oral Surg Oral Med Oral Pathol. 1979; 42: 656-678
- Chronic inflammation.J Endod. 1977; 3: 218-221
- Immunopathology [Teaching monograph].Am J Pathol. 1978; 90: 215-279
- The granulomatous inflammatory response: a review.Am J Pathol. 1976; 84: 164-192
- Granulomatous inflammation—a review.J Clin Pathol. 1983; 36: 723-733
- A functional classification of granulomatous inflammation.Ann NY Acad Sci. 1976; 278: 7-18
Article info
Identification
Copyright
© 1987 Published by Elsevier Inc.
