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Abstract
The incidence of regional lymph node metastasis in the hamster tongue carcinoma induced
by DMBA was studied. Metastasis to the regional lymph node was confirmed by histologic
examination in 25 (22.1%) of the 113 experimental animals. Of a total of 238 lymph
nodes examined, metastatic deposits were found in 35 (14.6%) lymph nodes. Systemic
administration of cortisone increased the rate of metastasis from 16.7% to 26.1%,
but the difference was not statistically significant. The necessity of extending the
tumor-bearing period and the addition of mechanical trauma to the primary carcinoma
to increase the rate of metastasis are stressed.
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© 1987 Published by Elsevier Inc.