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Abstract
Gamma-glutamyl transpeptidase (GGT) activity has been shown to increase in preneoplastic
cells in various experimental carcinogenesis models and in some human tumors. This
pilot study was undertaken to examine its potential use in detection of sites of human
oral carcinogeneis. Samples were taken from 16 surgical specimens: 12 resection specimens
for squamous carcinomas and 4 benign mucosal lesions. Twelve of the patients were
tobacco users. Diffuse GGT activity was found in all tobacco users and heavy cellular
activity in all carcinomas. In four of the carcinoma-resection specimens, occasional
cells staining heavily for GGT activity were noted in epithelium distant from the
tumor itself. These results are discussed in relation to the potential value of GGT
activity as a marker from preneoplastic changes in oral epithelium.
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© 1987 Published by Elsevier Inc.
