Research Article| Volume 64, ISSUE 2, P264-267, August 1987

Oral complications of high-dose melphalan in multiple myeloma

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      Four patients with multiple myeloma refractory to conventional chemotherapy received high-dose melphalan. All experienced multiple oral complications. Extensive neutropenic ulceration and orofacial herpes simplex virus infection caused considerable morbidity in three patients during prolonged periods of neutropenia.
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        • Packman CH
        • Leddy JP
        • Bakemeier RF
        Hypergammaglobulinemia: monoclonal and polyclonal states.
        in: Lichtman MA Hematology for practitioners. Little, Brown & Company, Boston1978: 247-276
        • Azar HA
        • Zarrio EC
        • Pham D
        • Yannopoulos K
        “Nonsecretory” plasma cell myeloma—observations on seven cases with electron microscope studies.
        Am J Clin Pathol. 1972; 58: 618-629
        • Kyle RA
        • Elveback LR
        Management and prognosis of multiple myeloma.
        in: Mayo Clin Proc. 51. 1976: 751-760
        • McElwain TJ
        • Powles RL
        High-dose intravenous melphalan for plasma-cell leukemia and myeloma.
        Lancet. 1983; 2: 822-824
        • Barlogie B
        • Hall R
        • Zander A
        • Dicke K
        • Alexanian R
        High-dose melphalan with autologous bone marrow transplantation for multiple myeloma.
        Blood. 1986; 67: 1298-1301
        • Barrett AP
        Evaluation of nystatin in prevention and elimination of oropharyngeal Candida in immunosuppressed patients.
        Oral Surg Oral Med Oral Pathol. 1984; 58: 148-151
        • Barrett AP
        Oral mucosal complications in cancer chemotherapy.
        Aust NZ J Med. 1984; 14: 7-12
        • Barrett AP
        Gingival lesions in leukemia: a classification.
        J Periodontol. 1984; 55: 585-588
        • Barrett AP
        Oral complications of bone marrow transplantation.
        Aust NZ J Med. 1986; 16: 239-240
        • Barrett AP
        Neutropenic ulceration: a distinctive clinical entity.
        J Periodontol. 1987; 58: 51-55
        • Barrett AP
        A long-term prospective clinical study of orofacial herpes simplex virus infection in acute leukemia.
        Oral Surg Oral Med Oral Pathol. 1986; 61: 149-152
        • Barrett AP
        • Buckley DJ
        • Greenberg ML
        • Earl MJ
        The value of exfoliative cytology in the diagnosis of oral herpes simplex infection in immunosuppressed patients.
        Oral Surg Oral Med Oral Pathol. 1986; 62: 175-178
        • Dreizen S
        • McCredie KB
        • Dicke DA
        • Zander AR
        • Peters LJ
        Oral complications of bone marrow transplantation in adults with acute leukemia.
        Postgrad Med. 1979; 66: 187-196
        • Palva IP
        • Ahrenberg P
        • Almquist K
        • et al.
        Aggressive combination chemotherapy in multiple myeloma.
        Scand J Haematol. 1985; 35: 205-209
        • Birgens HS
        • Hansen OP
        • Clausen NT
        A methodological evaluation of 14 controlled clinical trials in myelomatosis.
        Scand J Haematol. 1985; 35: 26-34
        • Zysset MK
        • Carlson RD
        • Montgomery MT
        • Redding SW
        Undiagnosed oral herpes in immunosuppressed patients.
        J Oral Med. 1986; 41: 70-74