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Abstract
The cause of aphthous stomatitis and erythema multiforme exudativum and the mechanics
involved in the disease processes remain obscure. Traumatic, physiologic, or severe
emotional stress is believed to play a role in the etiology of this condition, presumably
by interference with local tissue immunity and production of an environment conducive
to vesicular formation by release of an intercellular virus. Since gamma globulin
is known to contain antibodies against many bacteria and viruses, an attempt was made
to test and evaluate its therapeutic value in the treatment of various types of ulcerative
stomatitis suspected of having a viral origin. The results achieved in this series
of cases are sufficiently encouraging to warrant further clinical trial and observation.
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Reference
- Oral Herpetiform Lesions Treated With Gamma Globulin.Oral Surg., Oral Med. & Oral Path. 1958; 11: 266-274
- Recurrent Herpetic Gingivostomatitis Treated With Gamma Globulin.Oral Surg., Oral Med. & Oral Path. 1960; 13: 165-169
- Treatment of Herpes Zoster and Chicken Pox With Immune Globulin.A. M. A. Arch. Dermat. 1956; 73: 553-555
- Treatment of Acute Ulcerative Lesions of the Oral Cavity.Oral Surg., Oral Med. & Oral Path. 1957; 10: 1176-1182
- Isolation of Herpes Simplex Virus From a Patient With Erythema Multiforme Exudativum (Stevens-Johnson Syndrome).New England J. Med. 1958; 259: 473-475
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Copyright
© 1961 The C. V. Mosby Company. Published by Elsevier Inc.
