Research Article| Volume 14, ISSUE 7, P882-890, July 1961

Treatment of ulcerative lesions of the oral cavity with gamma globulin

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      The cause of aphthous stomatitis and erythema multiforme exudativum and the mechanics involved in the disease processes remain obscure. Traumatic, physiologic, or severe emotional stress is believed to play a role in the etiology of this condition, presumably by interference with local tissue immunity and production of an environment conducive to vesicular formation by release of an intercellular virus. Since gamma globulin is known to contain antibodies against many bacteria and viruses, an attempt was made to test and evaluate its therapeutic value in the treatment of various types of ulcerative stomatitis suspected of having a viral origin. The results achieved in this series of cases are sufficiently encouraging to warrant further clinical trial and observation.
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