Abstract
Objective: To test the effectiveness of 3 mouthwashes used to treat chemotherapy-induced mucositis.
The mouthwashes were as follows: salt and soda, chlorhexidine, and “magic” mouthwash
(lidocaine, Benadryl, and Maalox). Study Design: A randomized, double-blind clinical trial was implemented in 23 outpatient and office
settings. Participants were monitored from the time they developed mucositis until
cessation of the signs and symptoms of mucositis, or until they finished their 12-day
supply of mouthwash. All participants followed a prescribed oral hygiene program and
were randomly assigned a mouthwash. Nurses used the Oral Assessment Guide for initial
assessment and taught patients how to assess their own mouths, then phoned the patients
every other day to gather status reports. Results: In 142 of 200 patients, there was a cessation of the signs and symptoms of mucositis
within 12 days. No significant differences in time for the cessation of the signs
and symptoms were observed among the 3 groups. Conclusions: Given the comparable effectiveness of the mouthwashes, the least costly was salt
and soda mouthwash. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:39-47)
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Oral health care for the cancer patients.Eur J Cancer B Oral Oncol. 1996; 32B: 281-292
- A database for mucositis induced by chemotherapy.Eur J Cancer B Oral Oncol. 1995; 31B: 258-260
- A long-term prospective clinical study of oral complications during conventional chemotherapy for acute leukemia.Oral Surg Oral Med Oral Pathol. 1987; 63: 313-316
- Oral infections and fever in immunocompromised patients with haematologic malignancies.Eur J Clin Microbiol Infect Dis. 1989; 8: 207-213
- Failure of clindamycin to influence the course of severe oromucositis associated with streptococcal bacteraemia in allogenic bone marrow transplant recipients.Scand J Infect Dis. 1993; 25: 43-50
Dodd MJ, Lindsey AM, Larson P, Musci E, Thomas M, Dibble SL, et al. Coping and self-care of cancer families: nurse prospectus (final report, 1986-1990). Funded by the National Institutes of Health, RO1 NU 1440.
Dodd MJ, Lindsey AM, Stetz K, Lewis B, Holzemer W, Larson P, et al. Self-care interventions to decrease chemotherapy morbidity (final report, 1988-1992). Funded by the National Institutes of Health and the National Cancer Institute, RO1 CA 48312.
- Mouth care.in: Notes on symptom control in hospice and palliative care. : Hospice Education Institute, Essex1989: 188-190
- Xerostomia.in: Symptom Control. : Blackwell Scientific, Boston1989: 433-440
- Treatment of radiation side effects with oral pilocarpine.J Surg Oncol. 1989; 42: 272-276
- Mucositis management practices for hospitalized patients: national survey results.J Pain Symp Manage. 1995; 10: 510-520
- Impact of a systematic oral care protocol on stomatitis after chemotherapy.Cancer Nurs. 1979; 2: 185-199
- Stomatitis after chemotherapy.Am J Nurs. 1975; 75: 1349-1352
- Oral condition of patients with leukemia and severe aplastic anemia.Oral Surg Oral Med Oral Pathol. 1985; 60: 498-504
- Guidelines for oral hygiene, denture care, and nutrition in patients with oral complications.in: Oral complications of cancer chemotherapy. : Martinus Nijhoff, Boston1983: 151-168
- Management of infectious complications of bone marrow transplantation.Oncology. 1990; 4: 69-85
- Oral gram-negative bacilli in bone marrow transplant patients given chlorhexidine rinses.J Dent Res. 1989; 68: 1199-1204
- Oral hygiene measures for patients with cancer: part I.Cancer Nurs. 1980; 3: 347-356
- Oral hygiene measures for patients with cancer: part II.Cancer Nurs. 1980; 3: 427-432
- Oral hygiene measures for patients with cancer: part III.Cancer Nurs. 1981; 4: 29-35
- Alleviation of cytotoxic therapy-induced normal tissue damage.Semin Oncol. 1995; 22: 95-97
- Phase III controlled evaluation of Sucralfate to alleviate stomatitis in patients receiving Fluorouracil-based chemotherapy.J Clin Oncol. 1997; 15: 1235-1238
- A double blind, placebo controlled, randomized trial to evaluate the role of Tetrachlorodecaoxide in the management of chemotherapy-induced oral mucositis.J Pain Symp Manage. 1997; 14: 82-87
- Efficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone marrow transplantation.Oral Surg Oral Med Oral Pathol. 1992; 73: 682-689
- Control of oral mucositis and candidiasis in marrow transplantation: A prospective, double-blind trial of chlorhexidine digluconate oral rinse.Bone Marrow Transplant. 1988; 3: 483-493
- Therapeutic use of chlorhexidine in bone marrow transplant patients: case studies.Oral Surg Oral Med Oral Pathol. 1987; 63: 683-687
- Oral acyclovir for prevention of herpes simplex virus reactivated after marrow transplantation.Ann Intern Med. 1984; 100: 823-828
- Oropharyngeal mucositis complicating bone marrow transplantation: Prognostic factors and the effect of chlorhexidine mouth rinse.Bone Marrow Transplant. 1989; 4: 89-185
- Chlorhexidine prophylaxis for chemotherapy- and radiotherapy-induced stomatitis: a randomized double-blind trial.Oral Surg Oral Med Oral Pathol. 1990; 69: 331-338
- Alleviation of cytotoxic therapy-induced normal tissue damage.Semin Oncol. 1995; 22: 95-97
- Oral complications of acute leukemia: prophylactic impact of chlorhexidine mouth rinse regimen.Oral Surg Oral Med Oral Pathol. 1985; 60: 275-280
- Effects of chlorhexidine during immunosuppressive chemotherapy: a preliminary report.Oral Surg Oral Med Oral Pathol. 1993; 76: 441-448
- The mode of action of chlorhexidine.J Periodontal Res. 1973; 8: 68-75
- The effect of mouth rinses and topical application of chlorhexidine on the development of dental plaque and gingivitis.J Periodontal Res. 1970; 5: 79-83
- Two-year use of chlorhexidine in man: IV effect on various medical parameters.J Periodontal Res. 1976; 11: 158-164
- The effectiveness of a preventive regimen on the periodontal health of patients undergoing chemotherapy for leukemia and lymphoma.J Clin Periodontol. 1991; 18: 346-347
- Systemic effects of oral use of chlorhexidine gel in multihandicapped epileptic children.Scand J Dent Res. 1981; 89: 264-269
- A four month study on the side effects of chlorhexidine mouthwashes on 50 soldiers.Scand J Dent Res. 1982; 80: 10-17
- Randomized clinical trail of chlorhexidine versus placebo for prevention of oral mucositis in patients receiving chemotherapy.Oncol Nurs Forum. 1996; 23: 921-927
- Treatment of oral complications of leukemia.Oral Surg Oral Med Oral Pathol. 1977; 35: 469-477
- Oral care of the patients having head and neck irradiation.Am J Nurs. 1975; 75: 2146-2149
- Providing optimal oral health.Nurs Clin North Am. 1977; 12: 671-685
- Dental management of head and neck cancer patients.J Surg Oncol. 1980; 15: 265-281
- The PRO-SELF mouth aware program: an effective approach for reducing chemotherapy-induced mucositis.Cancer Nurs. 1998; 21: 263-268
- Development, testing, and application of the oral assessment guide.Oncol Nurs Forum. 1988; 15: 325-330
Article info
Publication history
Accepted:
December 27,
1999
Received in revised form:
July 28,
1999
Received:
June 14,
1999
Footnotes
*Funded by NIH, NCI, RO1 CA55555.
**Reprint requests: Marylin Dodd, RN, PhD, School of Nursing, Box 0610, University of California, San Francisco, San Francisco, CA 94143-0610
Identification
Copyright
© 2000 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
