Abstract
Objective. The purpose of this study was to conduct a complete analysis of the oral abnormalities
of patients with Marfan syndrome. Study Design. Twenty three patients with Marfan syndrome and 69 healthy controls were studied.
The subjects were screened for cariologic and periodontal alterations, as well as
structural defects of enamel and dentin. Data analysis was performed by using the
t test, the chi-square test, and regression models. Results. Patients aged 0 to 17 years were significantly at risk for caries. Local hypoplastic
enamel spots were more frequent in Marfan syndrome and could be related to caries
history of the deciduous dentition. Root deformity, abnormal pulp shape, and pulpal
inclusions were a frequent finding in patients with Marfan syndrome. Calculus and
gingival indices were significantly higher in the study group as well. Conclusions. This study shows the importance of early diagnosis of oral anomalies and timely treatment
of dental problems in Marfan syndrome. A series of therapeutic guidelines to be integrated
in treatment strategies is proposed. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:564-72)
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References
- 4th ed. Heritable disorders of connective tissue. : Mosby, St Louis1972: 68-71
- International nosology of heritable disorders of connective tissue, Berlin, 1986.Am J Med Genet. 1988; 29: 581-594
- Four novel FBN1 mutations: significance for mutant transcript level and EGF-like domain calcium binding in the pathogenesis of Marfan syndrome.Genomics. 1993; 17: 468-475
- Progression of aortic dilatation and the benefit of long-term β-adrenergic blockade in Marfan's syndrome.N Engl J Med. 1994; 330: 1335-1341
- Life expectancy in the Marfan syndrome.Am J Cardiol. 1995; 75: 157-160
- Revised diagnostic criteria for the Marfan syndrome.Am J Med Genet. 1996; 62: 417-426
- Location on chromosome 15 of the gene defect causing Marfan syndrome.N Engl J Med. 1990; 323: 935-939
- Fibrillin-2 (FBN2) mutations result in the Marfan-like disorder, congenital contractural arachnodactyly.Nature Genet. 1995; 11: 456-458
- The Marfan Syndrome: diagnosis and management.N Engl J Med. 1979; 300: 772-777
- Syndromes of head and neck. : Oxford Univ Press, Oxford (UK)1990: 267-272
- Genetic craniofacial aberrations.Acta Odontol Scand. 1998; 56: 356-359
- Severe maxillary arch constriction in a patient with Marfan's syndrome: report of a case.ASDC J Dent Child. 1981; 48: 292-293
- Palatal dimensions and some inherited factors (body weight and metacarpal index).Swed Dent J. 1996; 20: 141-149
- Craniofacial manifestations in the Marfan syndrome: palatal dimensions and a comparative cephalometric analysis.J Craniofac Genet Dev Biol. 1998; 18: 211-218
- Marfan's syndrome in Northern Ireland.Ann Hum Genet. 1958; 22: 289-301
- Marfan's syndrome: description of a family.Am J Med. 1957; 23: 434-444
- Bilateral aniridia with Marfan's syndrome: a new association.Jpn J Ophthalmol. 1986; 30: 360-366
- Comparative ultrastructure studies of gingiva and pulp in the Marfan syndrome and homocystinuria.Am J Med Genet. 1989; 32: 242
- Oral Health Surveys, Basic Methods.2nd ed. : WHO, Geneva1978
- 7th ed. Pickard's manual of operative dentistry. : Oxford University Press, Oxford (UK)1996: 9-32
- Commonly used indices to assess oral hygiene and gingival and periodontal health and diseases.in: Proceedings of the European Workshop on Mechanical Plaque Control—Berne, Switzerland, May 9-12, 1998 Quintessence Publishing Co, 1998: 50-71
- A proposed classification for heritable human dentine defects with a description of a new entity.in: Arch Oral Biol. 18. 1973: 543-553
- MedCalc: a new computer program for medical statistics.Comp Methods Progr Biomed. 1995; 48: 257-262
- Statistical models in epidemiology. : Oxford Univ Press, Oxford (UK)1993
- 2nd ed. Statistical methods in medical research. : Blackwell Ed, Oxford (UK)1987
- Statistics and ethics in medical research. VI. Presentation of results.Br Med J. 1980; 281: 1542-1544
- Epidemiology in dentistry. : Bohn, Scheltema & Holtema, Utrecht/Antwerp1981: 77
- An echocardiographic study of patients with cardiovascular disease during dental treatment using local anesthesia.J Oral Maxillofac Surg. 1986; 44: 116-121
- Systemic management of Marfan's syndrome during dental treatment: a case report.Anesth Pain Control Dent. 1993; 2: 162-170
- Exclusion of the alpha 2(I) and alpha 1(III) collagen genes as the mutant loci in a Marfan syndrome family.J Med Genet. 1987; 24: 148-151
- Immunohistologic abnormalities of the microfibrillar fiber-system in the Marfan syndrome.N Engl J Med. 1990; 323: 152-159
- Genetic linkage of the Marfan syndrome, ectopia lentis, and congenital contractural arachnodactyly to the fibrillin genes on chromosomes 15 and 5.N Engl J Med. 1994; 326: 905-909
Article info
Publication history
Accepted:
October 24,
2001
Received in revised form:
August 31,
2001
Received:
March 12,
2001
Footnotes
*Reprint requests: P. J. A. De Coster, DDS Dept Paediatric Dentistry Centre for Special Care De Pintelaan 185 (P 8) B-9000 GENT - BELGIUM [email protected]
Identification
Copyright
© 2002 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
