Abstract
Objective. Oral candidiasis is associated with multiple local and systemic factors. Morbidity
and deaths, in high-risk patients, may be prevented by recognition and adequate management.
Fluconazole is a systemic antifungal medication that demonstrated clinical advantages
in rinsing before swallowing. The purpose of the present study was to evaluate the
clinical efficacy of fluconazole aqueous mouthrinses to treat oral candidiasis. Methods. Ten women and 9 men diagnosed with oral candidiasis used fluconazole (2 mg/mL) aqueous
solution 3 times per day as a rinse and-spit topical treatment. The outcome was assessed
after 1 week of treatment. Results. Complete symptomatic and clinical relief was noted in 94% of the patients, and a
mycologic cure was documented in all but 1 patient. No side effects were reported.
Oral rinses with fluconazole suspension may be useful to manage patients with dry
mouth or those who have difficulties in swallowing caused by oral candidiasis. Conclusions. Further double-blind studies are needed to establish the optimal treatment regimen
and the usefulness of fluconazole mouthrinses in patients with different risk factors
for infection. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:671-5)
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Article info
Publication history
Accepted:
November 27,
2001
Received in revised form:
August 31,
2001
Received:
June 5,
2001
Footnotes
*aHead, Department of Dentistry, Vancouver Hospital and Health Sciences Centre, British Columbia, Canada; Professor and Head, Division of Hospital Dentistry British Columbia, University of British Columbia; Medical-Dental Staff, British Columbia Cancer Agency; and Research Associate Professor, University of Washington, Seattle.
**bProfessor, Department of Oral Pathology and Oral Medicine, the Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
*cFormerly, Senior Resident, University of British Columbia, Vancouver, Canada; British Columbia Cancer Agency and Vancouver Hospital. Currently, in private practice, Vancouver, British Columbia, Canada.
**Reprint requests: Joel Epstein, DMD, MSD, FRCD(C), Department of Dentistry, British Columbia Cancer Agency, 600 West 10th Ave, Vancouver, British Columbia, Canada V5Z 4E6 [email protected]
Identification
Copyright
© 2002 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
