Abstract
Objective. Pathologists have drawn attention to the invasive tumor front (ITF) in the determination
of the biologic aggressiveness of oral cancer. We have attempted to discover the prognostic
significance of cancer cells with abnormal DNA content at the ITF of oral squamous
cell carcinoma. Study Design. A comparative DNA analysis by means of image cytometry and flow cytometry was conducted
to confirm the usefulness of image cytometry in detecting cancer cells having abnormal
DNA content at the ITF. The prognostic value of cancer cells with abnormal DNA content
ws examined by a multivariate analysis for 195 patients with oral squamous cell carcinoma.
Results. In the comparative DNA analysis, it was suggested that image cytometry is useful
for detecting cancer cells with abnormal DNA content (4c exceeding rate [4cER]), which
is associated with poor prognosis of patients with oral squamous cell carcinoma. In
the multivariate analysis, 3 independent factors were found to significantly influence
cause-specific survival. These are, in decreasing order of influence, (1) abnormal
DNA content (4cER), (2) clinical stage, and (3) growth type. Conclusion. The presence of cancer cells with abnormal DNA content of the ITF in conjunction
with clinical findings (clinical stage and growth type) can give additional useful
information when selecting treatment strategies for oral cancer patients. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:682-7)
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Article info
Publication history
Accepted:
December 4,
2001
Received:
July 31,
2001
Footnotes
*aDepartment of Oral Surgery, Sapporo Medical University School of Medicine, Japan.
**bDepartment of Oral and Maxillofacial Surgery, School of Medicine, University of the Ryukyus, Okinawa, Japan.
*Reprint requests: Makoto Noguchi, DDS, PhD, Department of Oral Surgery, Sapporo Medical University School of Medicine, South 1 West 16, Chuo-ku, Sapporo, 060-0061, Hokkaido, Japan, [email protected]
Identification
Copyright
© 2002 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
