Abstract
Calcifying epithelial odontogenic tumor (CEOT) is a rare benign, but locally aggressive,
odontogenic tumor, and only 2 cases of malignant CEOT are reported in the literature.
We describe a case of an atypical CEOT that penetrates the blood vessels, invades
bone, and perforates the cortical plates of the mandible. On histologic examination,
it shows marked pleomorphism and numerous mitotic figures, including a tripolar mitotic
figure. Proliferating activity was found to be 5 times higher than typical CEOTs as
demonstrated by the proliferating index, Ki-67, and analyzed by a computerized image
analysis system. The Ki-67 labeling index of this case was also compared to various
previously reported benign and malignant neoplasms. Although there is no clinical
finding of metastasis, we believe this neoplasm has malignant potential on the basis
of the histologic features of vascular invasion, significant mitotic activity, atypical
mitotic figures, and an increased proliferating index. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:287-95)
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Article info
Publication history
Accepted:
October 25,
2001
Received in revised form:
September 14,
2001
Received:
July 9,
2002
Footnotes
*Reprint requests: Yi-Shing Lisa Cheng, DDS, MS, PhD, Diagnostic Sciences, Baylor College of Dentistry-TAMUS, 3302 Gaston Ave, Dallas, TX 75246, [email protected]
Identification
Copyright
© 2002 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
