Abstract
Objectives: The purpose of this study was to determine the prevalence and concurrence/associations
of oral candidiasis types and multiple risk factors in women. Study Design: A cross-sectional analysis of baseline data for 577 human immunodeficiency virus
(HIV)–seropositive and 152 HIV-seronegative women from the Women's Interagency HIV
Study was conducted. Pseudomembranous candidiasis (PC) and erythematous (EC) candidiasis,
angular cheilitis (AC), and denture stomatitis (DS) were studied, and bivariate and
multivariate regression analyses were performed. Results: Prevalences were 8% for PC, 7% for EC, 18% for DS, and 3% for AC; all except AC usually
occurred alone. HIV seropositivity was associated with PC, EC, and DS, but not AC.
Among HIV-seropositive women, low CD4 cell counts were associated with PC, but not
with EC or DS. Heroin/methadone use was associated with PC and EC; salivary hypofunction
was associated with PC; high viral load was associated with EC, and poor oral hygiene,
with EC and DS. Conclusions: Risk factors varied among candidiasis types, suggesting differences in pathogenic
mechanisms and usefulness as markers of HIV infection/progression. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:45-55)
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Article info
Publication history
Accepted:
August 29,
2001
Received in revised form:
June 4,
2001
Received:
March 22,
2001
Footnotes
*Supported by NIH cooperative agreement #U01 A134989 and NIDCR.
**Reprint requests: Reprint requests: Laurie MacPhail, PhD, DMD, Department of Oral & Maxillofacial Pathology, Medicine and Surgery, Temple University School of Dentistry, 3223 N Broad St, Philadelphia, PA 19140, [email protected]
Identification
Copyright
© 2002 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
