Abstract
The development of secondary malignancies has been recognized as a potential iatrogenic
complication in patients who have graft-versus-host disease secondary to bone marrow
transplantation. Lymphohematopoietic cancer is most frequent, although solid malignancies
have also been reported. We describe 2 patients with graft-versus-host disease who
developed oral precancerous and malignant lesions. The first patient, a 24-year-old
white man, had erythroplakia of the buccal mucosa that proved to be carcinoma in situ
histopathologically. The second patient, a 14-year-old Hispanic boy, developed synchronous
cutaneous and lingual squamous cell carcinomas. The current cases and similar sporadic
case reports found in the literature highlight the susceptibility of patients with
graft-versus-host disease to the development of oral cancer. Therefore, it is recommended
that thorough evaluation of the oral mucosa and close follow-up be offered to all
patients treated with bone marrow transplantation and particularly to those who develop
graft-versus-host disease. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:75-80)
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Allogeneic bone-marrow transplantation.Immunol Rev. 1983; 71: 77-102
- Secondary malignancies after marrow transplantation.Exp Hematol. 1984; 12: 660-666
- Oral and maxillofacial pathology.in: 1st ed. : W.B. Saunders, Philadelphia1995: 577-578
- In vitro regulation of immunoglobulin synthesis after marrow transplantation. I. T-cell and B-cell deficiencies in patients with and without chronic graft-versus-host disease.in: Blood. 58. 1981: 431-439
- Acute and chronic graft-versus-host disease in man.Int J Cell Cloning. 1986; 4: 42-93
- Cancer following medical irradiation.Cancer. 1981; 47: 1081-1090
- Incidence of second primary tumours among childhood cancer survivors.Br J Cancer. 1987; 56: 339-347
- Malignancies after marrow transplantation for aplastic anemia and Fanconi anemia: a joint Seattle and Paris analysis of results in 700 patients.Blood. 1996; 87: 386-392
- Secondary cancers after bone marrow transplantation for leukemia or aplastic anemia.N Engl J Med. 1989; 321: 784-789
- Bone marrow transplantation: a review of delayed complications.Br J Haematol. 1984; 57: 185-208
- Cutaneous and mucosal neoplasms in bone marrow transplant recipients.Cancer. 1990; 65: 473-476
- Anaplastic squamous cell carcinoma (SCC) in a patient with chronic cutaneous graft-versus-host disease (GVHD).Bone Marrow Transplant. 1999; 23: 1197-1199
- Graft versus host disease in a liver transplant patient with hepatitis B and hepatocellular carcinoma.Transplant Proc. 1999; 31: 1890-1891
- Bronchial mucoepidermoid carcinoma after allogeneic bone marrow transplantation.J Clin Pathol. 1997; 50: 969-970
- Increased incidence of solid malignant tumors after bone marrow transplantation for severe aplastic anemia.Blood. 1991; 78: 277-279
- Gingival squamous cell carcinoma in a patient with chronic graft-versus-host disease.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997; 84: 171-174
- Oral squamous cell carcinoma after allogeneic bone marrow transplantation for Fanconi anaemia.Br J Haematol. 1997; 99: 410-414
- Squamous carcinoma of the head and neck in organ transplant recipients: possible role of oncogenic viruses.Laryngoscope. 1990; 100: 190-194
- Marrow transplantation for Fanconi anemia with or without leukemic transformation: an update of the Seattle experience.Bone Marrow Transplant. 1992; 9: 167-173
- Secondary malignancies after bone marrow transplantation in adults.J Clin Oncol. 1994; 12: 2187-2192
- Topical cyclosporin A for treatment of oral chronic graft-versus-host disease.Bone Marrow Transplant. 1994; 13: 81-86
- Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia.N Engl J Med. 1986; 314: 729-735
- Risk factors for the development of secondary malignancies after marrow transplantation.Hematol Oncol Clin North Am. 1993; 7: 417-429
Article info
Publication history
Accepted:
August 14,
2001
Received in revised form:
August 7,
2001
Received:
July 20,
2001
Footnotes
*Reprint requests: Rafik A. Abdelsayed, DDS, MS, Associate Professor, Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, [email protected]
Identification
Copyright
© 2002 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
