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Oral and maxillofacial surgery| Volume 109, ISSUE 3, P335-345, March 2010

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Risk factors associated with injury to the inferior alveolar and lingual nerves following third molar surgery—revisited

Published:January 25, 2010DOI:https://doi.org/10.1016/j.tripleo.2009.10.010

      Objective

      Earlier reports, including a preliminary study within our unit, have shown that the surgeon's experience is one of the most influential factors in determining the likelihood of both permanent inferior alveolar nerve (IAN) and lingual nerve (LN) paresthesia, following third molar surgery. The effect of this and other factors influencing such prevalence are assessed in this study.

      Study design

      This prospective study involved 3236 patients who underwent surgical removal of impacted third molars. Patients' demographics and radiological parameters were recorded along with the grade of the treating surgeon. The prevalence of inferior alveolar and lingual nerves paresthesia at 1 month, 6 months, and 18 to 24 months postoperatively were also traced.

      Results

      At 1 month postoperatively, the incidence of IAN paresthesia was 1.5% and the LN was 1.8%. These figures decreased over time and 18 to 24 months postoperatively, the incidence of permanent dysfunction of the IAN was 0.6% and LN was 1.1%. With regard to inferior alveolar nerve paresthesia, risk factors included the patient's age (26-30 years), horizontally impacted teeth, close radiographic proximity to the inferior alveolar canal (IAC), and treatment by trainee surgeons. With regard to the lingual nerve, risk factors included male patients, distoangular impactions, close radiographic proximity to the IAC, and treatment by trainee surgeons.

      Conclusion

      One of the main risk factors of developing permanent sensory dysfunction in the distribution of these nerves is related to the surgical skills/experience of the operator. Other factors are associated with the type of impaction and the radiographic proximity of the tooth to the inferior alveolar nerve. Such long-term complications can affect the patient's quality of life; the impact on profession, education, and research is unknown.
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      References

        • Loescher A.R.
        • Smith K.G.
        • Robinson P.P.
        Nerve damage and third molar removal.
        Dent Update. 2003; 30: 375-382
        • Ramadas Y.
        • Sealey C.M.
        Third molar removal and nerve injury.
        N Z Dent J. 2001; 97: 25-28
        • Tay A.B.
        • Zuniga J.R.
        Clinical characteristics of trigeminal nerve injury referrals to a university centre.
        Int J Oral Maxillofac Surg. 2007; 36: 922-927
        • Hillerup S.
        Iatrogenic injury to oral branches of the trigeminal nerve: records of 449 cases.
        Clin Oral Investig. 2007; 11: 133-142
        • Libersa P.
        • Savignat M.
        • Tonnel A.
        Neurosensory disturbances of the inferior alveolar nerve: a retrospective study of complaints in a 10-year period.
        J Oral Maxillofac Surg. 2007; 65: 1486-1489
        • Fielding A.F.
        • Rachiele D.P.
        • Frazier G.
        Lingual nerve paresthesia following third molar surgery: a retrospective clinical study.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997; 84: 345-348
        • Sisk A.L.
        • Hammer W.B.
        • Shelton D.W.
        • Joy Jr, E.D.
        Complications following removal of impacted third molars: the role of the experience of the surgeon.
        J Oral Maxillofac Surg. 1986; 44: 855-859
        • Lopes V.
        • Mumenya R.
        • Feinmann C.
        • Harris M.
        Third molar surgery: an audit of the indications for surgery, post-operative complaints and patient satisfaction.
        Br J Oral Maxillofac Surg. 1995; 33: 33-35
        • Chiapasco M.
        • De Cicco L.
        • Marrone G.
        Side effects and complications associated with third molar surgery.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1993; 76: 412-420
        • Middlehurst R.J.
        • Barker G.R.
        • Rood J.P.
        Postoperative morbidity with mandibular third molar surgery: a comparison of two techniques.
        J Oral Maxillofac Surg. 1988; 46: 474-476
        • Kipp D.P.
        • Goldstein B.H.
        • Weiss Jr, W.W.
        Dysesthesia after mandibular third molar surgery: a retrospective study and analysis of 1,377 surgical procedures.
        J Am Dent Assoc. 1980; 100: 185-192
        • Wofford D.T.
        • Miller R.I.
        Prospective study of dysesthesia following odontectomy of impacted mandibular third molars.
        J Oral Maxillofac Surg. 1987; 45: 15-19
        • Rood J.P.
        • Shehab B.A.
        The radiological prediction of inferior alveolar nerve injury during third molar surgery.
        Br J Oral Maxillofac Surg. 1990; 28: 20-25
        • Osborn T.P.
        • Frederickson Jr, G.
        • Small I.A.
        • Torgerson T.S.
        A prospective study of complications related to mandibular third molar surgery.
        J Oral Maxillofac Surg. 1985; 43: 767-769
        • Alling 3rd, C.C.
        Dysesthesia of the lingual and inferior alveolar nerves following third molar surgery.
        J Oral Maxillofac Surg. 1986; 44: 454-457
        • Ewers R.
        • Hoffmeister B.
        Functional disorders of the mandibular nerve caused by the molars.
        Z Stomatol. 1986; 83: 521-535
        • Carmichael F.A.
        • McGowan D.A.
        Incidence of nerve damage following third molar removal: a West of Scotland Oral Surgery Research Group study.
        Br J Oral Maxillofac Surg. 1992; 30: 78-82
        • Rood J.P.
        Lingual split technique.
        Br Dent J. 1983; 154: 402-403
        • Jerjes W.
        • Swinson B.
        • Moles D.R.
        • El-Maaytah M.
        • Banu B.
        • Upile T.
        • et al.
        Permanent sensory nerve impairment following third molar surgery: a prospective study.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 102: e1-e7
        • Sunderland S.
        A classification of peripheral nerve injuries producing loss of function.
        Brain. 1951; 74: 491-516
        • Blackburn C.W.
        • Bramley P.A.
        Lingual nerve damage associated with the removal of lower third molars.
        Br Dent J. 1989; 167: 103-107
        • Gerlach K.L.
        • Hoffmeister B.
        • Walz C.
        Dysesthesia and anesthesia of the mandibular nerve following dental treatment.
        Dtsch Zahnarztl Z. 1989; 44: 970-972
        • Tay A.B.
        • Go W.S.
        Effect of exposed inferior alveolar neurovascular bundle during surgical removal of impacted lower third molars.
        J Oral Maxillofac Surg. 2004; 62: 592-600
        • Goldberg M.H.
        • Nemarich A.N.
        • Marco 2nd, W.P.
        Complications after mandibular third molar surgery: a statistical analysis of 500 consecutive procedures in private practice.
        J Am Dent Assoc. 1985; 111: 277-279
        • Miura K.
        • Kino K.
        • Shibuya T.
        • Hirata Y.
        • Shibuya T.
        • Sasaki E.
        • et al.
        Nerve paralysis after third molar extraction.
        Kokubyo Gakkai Zasshi. 1998; 65: 1-5
        • Brann C.R.
        • Brickley M.R.
        • Shepherd J.P.
        Factors influencing nerve damage during lower third molar surgery.
        Br Dent J. 1999; 186: 514-516
        • Genú P.R.
        • Vasconcelos B.C.
        Influence of the tooth section technique in alveolar nerve damage after surgery of impacted lower third molars.
        Int J Oral Maxillofac Surg. 2008; 37: 923-928
        • Kiesselbach J.E.
        • Chamberlain J.G.
        Clinical and anatomic observations on the relationship of the lingual nerve to the mandibular third molar region.
        J Oral Maxillofac Surg. 1984; 42: 565-567
        • Malden N.J.
        • Maidment Y.G.
        Lingual nerve injury subsequent to wisdom teeth removal—a 5-year retrospective audit from a high street dental practice.
        Br Dent J. 2002; 193: 203-205
        • Gomes A.C.
        • Vasconcelos B.C.
        • de Oliveira e Silva E.D.
        • da Silva L.C.
        Lingual nerve damage after mandibular third molar surgery: a randomized clinical trial.
        J Oral Maxillofac Surg. 2005; 63: 1443-1446
        • Pedersen G.W.
        Oral surgery.
        in: Saunders, Philadelphia1988: 60-81
        • Bataineh A.B.
        Sensory nerve impairment following mandibular third molar surgery.
        J Oral Maxillofac Surg. 2001; 59: 1012-1017
        • Appiah-Anane S.
        • Appiah-Anane M.G.
        Protection of the lingual nerve during operations on the mandibular third molar: a simple method.
        Br J Oral Maxillofac Surg. 1997; 35: 170-172
        • Mason D.A.
        Lingual nerve damage following lower third molar surgery.
        Int J Oral Maxillofac Surg. 1988; 17: 290-294
        • Gulicher D.
        • Gerlach K.L.
        Sensory impairment of the lingual and inferior alveolar nerves following removal of impacted mandibular third molars.
        Int J Oral Maxillofac Surg. 2001; 30: 306-312
        • Robinson P.P.
        • Smith K.G.
        Lingual nerve damage during lower third molar removal: a comparison of two surgical methods.
        Br Dent J. 1996; 180: 456-461
        • Rood J.P.
        Permanent damage to inferior alveolar and lingual nerves during the removal of impacted mandibular third molars.
        Br Dent J. 1992; 172: 108-110
        • Absi E.G.
        • Shepherd J.P.
        A comparison of morbidity following the removal of lower third molars by the lingual split and surgical bur methods.
        Int J Oral Maxillofac Surg. 1993; 22: 149-153
        • Greenwood M.
        • Langton S.G.
        • Rood J.P.
        A comparison of broad and narrow retractors for lingual nerve protection during lower third molar surgery.
        Br J Oral Maxillofac Surg. 1994; 32: 114-117
        • Pichler J.W.
        • Beirne O.R.
        Lingual flap retraction and prevention of lingual nerve damage associated with third molar surgery: a systematic review of the literature.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 91: 395-401
        • Gargallo-Albiol J.
        • Buenechea-Imaz R.
        • Gay-Escoda C.
        Lingual nerve protection during surgical removal of lower third molars.
        Int J Oral Maxillofac Surg. 2000; 29: 268-271
        • Chossegros C.
        • Guyot L.
        • Cheynet F.
        • Belloni D.
        • Blanc J.L.
        Is lingual nerve protection necessary for lower third molar germectomy?.
        Int J Oral Maxillofac Surg. 2002; 31: 620-624
        • Krafft T.C.
        • Hickel R.
        Clinical investigation into the incidence of direct damage to the lingual nerve caused by local anesthesia.
        J Craniomaxillofac Surg. 1994; 22: 294-296
        • Rud J.
        The split-bone technic for removal of impacted mandibular third molars.
        J Oral Surg. 1970; 28: 416-421
        • Bruce R.A.
        • Frederickson G.C.
        • Small G.S.
        Age of patients and morbidity associated with mandibular third molar surgery.
        J Am Dent Assoc. 1980; 101: 240-245
        • Black C.G.
        Sensory impairment following lower third molar surgery: a prospective study in New Zealand.
        N Z Dent J. 1997; 93: 68-71
        • Valmaseda-Castellon E.
        • Berini-Aytes L.
        • Gay-Escoda C.
        Inferior alveolar nerve damage after lower third molar surgical extraction: a prospective study of 1117 surgical extractions.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 92: 377-383
        • Miloro M.
        • DaBell J.
        Radiographic proximity of the mandibular third molar to the inferior alveolar canal.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 100: 545-549
        • Jerjes W.
        • El-Maaytah M.
        • Swinson B.
        • Upile T.
        • Thompson G.
        • Gittelmon S.
        • et al.
        Inferior alveolar nerve injury and surgical difficulty prediction in third molar surgery: the role of dental panoramic tomography.
        J Clin Dent. 2006; 17: 122-130
        • Visintini E.
        • Angerame D.
        • Costantinides F.
        • Maglione M.
        Peripheral neurological damage following lower third molar removal.
        Minerva Stomatol. 2007; 56: 319-326
        • Renton T.
        • Hankins M.
        • Sproate C.
        • McGurk M.
        A randomised controlled clinical trial to compare the incidence of injury to the inferior alveolar nerve as a result of coronectomy and removal of mandibular third molars.
        Br J Oral Maxillofac Surg. 2005; 43: 7-12
        • Pogrel M.A.
        • Lee J.S.
        • Muff D.F.
        Coronectomy: a technique to protect the inferior alveolar nerve.
        J Oral Maxillofac Surg. 2004; 62: 1447-1452
        • Barron R.P.
        • Benoliel R.
        • Zeltser R.
        • Eliav E.
        • Nahlieli O.
        • Gracely R.H.
        Effect of dexamethasone and dipyrone on lingual and inferior alveolar nerve hypersensitivity following third molar extractions: preliminary report.
        J Orofac Pain. 2004; 18: 62-68
        • Pogrel M.A.
        • Thamby S.
        The etiology of altered sensation in the inferior alveolar, lingual, and mental nerves as a result of dental treatment.
        J Calif Dent Assoc. 1999; 27: 534-538
        • Gulicher D.
        • Gerlach K.L.
        Incidence, risk factors and follow-up of sensation disorders after surgical wisdom tooth removal.
        Mund Kiefer Gesichtschir. 2000; 4: 99-104
        • Blondeau F.
        • Daniel N.G.
        Extraction of impacted mandibular third molars: postoperative complications and their risk factors.
        J Can Dent Assoc. 2007; 73: 325
        • Capuzzi P.
        • Montebugnoli L.
        • Vaccaro M.A.
        Extraction of impacted third molars.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1994; 77: 341-343
        • Hill C.M.
        • Mostafa P.
        • Thomas D.W.
        • Newcombe R.G.
        • Walker R.V.
        Nerve morbidity following wisdom tooth removal under local and general anesthesia.
        Br J Oral Maxillofac Surg. 2001; 39: 419-422
        • Meyer R.A.
        Evaluation and management of neurologic complications.
        in: Kaban L.B. Pogrel M.A. Perrott D.H. Complications in oral and maxillofacial surgery. Saunders, Philadelphia1997: 69
        • Pogrel M.A.
        Complications of third molar surgery.
        in: Kaban L.B. Pogrel M.A. Perrott D.H. Complications in oral and maxillofacial surgery. Saunders, Philadelphia1997: 59
        • Girard K.R.
        Considerations in the management of damage to the mandibular nerve.
        J Am Dent Assoc. 1979; 98: 65-71
        • Robinson P.P.
        Observations on the recovery of sensation following inferior alveolar nerve injuries.
        Br J Oral Maxillofac Surg. 1988; 26: 177-189
        • Robinson P.P.
        • Loescher A.R.
        • Yates J.M.
        • Smith K.G.
        Current management of damage to the inferior alveolar and lingual nerves as a result of removal of third molars.
        Br J Oral Maxillofac Surg. 2004; 42: 285-292
        • van der Glas H.W.
        • van der Rijt E.E.
        • van der Bilt A.
        • Koole R.
        • Vriens J.P.
        Testing of iatrogenic lingual nerve injury using a novel psychophysical method and oral reflexes.
        Int J Oral Maxillofac Surg. 2007; 36: 545-549
        • Ghali G.E.
        • Jones D.L.
        • Wolford L.M.
        Somatosensory evoked potential assessment of the inferior alveolar nerve following third molar extraction.
        Int J Oral Maxillofac Surg. 1990; 19: 18-21
        • Renton T.
        • Thexton A.
        • Hankins M.
        • McGurk M.
        Quantitative thermosensory testing of the lingual and inferior alveolar nerves in health and after iatrogenic injury.
        Br J Oral Maxillofac Surg. 2003; 41: 36-42
        • Trost O.
        • Kazemi A.
        • Cheynel N.
        • Benkhadra M.
        • Soichot P.
        • Malka G.
        • et al.
        Spatial relationships between lingual nerve and mandibular ramus: original study method, clinical and educational applications.
        Surg Radiol Anat. 2009; 31: 447-452
        • Yachouh J.
        • Jammet P.
        • Bensaha T.
        • Goudot P.
        Lingual nerve injury during removal of the lower third molar: importance of early intervention.
        Rev Stomatol Chir Maxillofac. 2006; 107: 393-396
        • Renton T.
        • McGurk M.
        Evaluation of factors predictive of lingual nerve injury in third molar surgery.
        Br J Oral Maxillofac Surg. 2001; 39: 423-428
        • Farole A.
        • Jamal B.T.
        A bioabsorbable collagen nerve cuff (NeuraGen) for repair of lingual and inferior alveolar nerve injuries: a case series.
        J Oral Maxillofac Surg. 2008; 66: 2058-2062
        • Ka L.
        • Hirata Y.
        • Kobayashi A.
        • Wake H.
        • Kino K.
        • Amagasa T.
        Treatment results of acupuncture in inferior alveolar and lingual nerves sensory paralysis after oral surgery.
        Kokubyo Gakkai Zasshi. 2006; 73: 40-46
        • Jerjes W.
        • Hopper C.
        • Kumar M.
        • Upile T.
        • Madland G.
        • Newman S.
        • et al.
        Psychological intervention in acute dental pain: review.
        Br Dent J. 2007; 202: 337-343