Objective
The purpose of this clinical prospective, randomized, double-blind study was to compare
the anesthetic efficacy of 4% articaine with epinephrine (1:100,000) and without epinephrine
in inferior alveolar nerve block anesthesia for extractions of mandibular teeth.
Study Design
Eighty-eight patients received intraoral inferior alveolar nerve blocks using 4% articaine
with 1:100,000 epinephrine (n = 41; group 1) or without epinephrine (n = 47; group
2) for extractions of mandibular teeth. The primary objectives were differences in
onset as well as in length of soft tissue anesthesia. The amount of anesthetic solution,
need of a second injection, pain while injecting, pain during treatment, postoperative
pain, and possible complications were surveyed.
Results
In both groups, anesthesia was sufficient for dental extractions. In group 1, a significantly
faster onset of the anesthetic effect (7.2 min vs. 9.2 min; P = .001) and a significantly longer duration of soft tissue anesthesia (3.8 h vs.
2.5 h; P < .0001) were seen. There was no significant difference in the amount of anesthetic
solution needed, in the need for a second injection, in the injection pain, in pain
during treatment, or in postoperative analgesia. In both groups, no complications
were seen.
Conclusions
To minimize the epinephrine-induced side effects, 4% articaine without epinephrine
is a suitable anesthetic agent for dental extractions in the mandible after inferior
alveolar nerve block anesthesia. There could be less postoperative discomfort due
to the shorter duration of anesthesia without increased postoperative pain.
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Article info
Publication history
Published online: August 08, 2011
Accepted:
April 29,
2011
Received in revised form:
March 26,
2011
Received:
February 10,
2011
Identification
Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
