Objective
The aim was to evaluate the effects of a new folkloric medicinal plant extract on
peripheral nerve function compared with oxidized regenerated cellulose (OC) and bovine
collagen (BC).
Study Design
Under ketamine anesthesia a total of 40 male Sprague-Dawley rat right sciatic nerves
were identified. Animals were randomly divided into 5 groups: OC, BC, ankaferd blood
stopper (ABS), and negative and positive control groups. The recordings of nerve potentials
were carried out using an electrophysiologic data acquisition system. After the application
of substances, the nerve conduction velocity (NCV) was recorded for immediate (30
min), early (120 min), and delayed (3 wk) effects on nerve function.
Results
Statistically, differences were not found among the hemostatic agents (OC, BC, and
ABS) at baseline and all tested periods (early, immediate, and delayed; P > .05). The positive control group exhibited lower NCV values compared with the other
solutions at the 30-minute period (P < .05) as well as the other tested time periods (P > .05). OC exhibited NCV values closer to the positive control group at 120 minutes
(P > .05).
Conclusions
Folkloric medicinal hemostatic agent could be considered as an acceptable hemostatic
material without resulting in any serious peripheral nerve function alterations. The
possible desirable effects of bovine collagen and undesirable effects of oxidized
cellulose on peripheral nerve function should not be overlooked.
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Article info
Publication history
Published online: May 31, 2012
Accepted:
October 24,
2011
Received in revised form:
October 17,
2011
Received:
April 22,
2011
Identification
Copyright
© 2013 Published by Elsevier Inc. All rights reserved.
