IgG4-related sclerosing disease is a distinct clinicopathologic entity known to involve
the maxillofacial region, particularly the salivary, lacrimal, and pituitary glands.
We report a case with lesions involving the tongue and palatine tonsil with associated
skin lesions. A 45-year-old female patient presented with a history of soreness, dysphagia,
and an asymptomatic rash involving the upper trunk. The initial clinical diagnosis
of her oral lesions was squamous cell carcinoma. The diagnosis of an IgG4-related
lesion was confirmed by histologic examination of the oral and skin lesions as well
as confirmation of raised serum IgG4 levels. Tapering systemic corticosteroid therapy
resulted in complete resolution of the lesions. This is the first report of IgG4-related
sclerosing disease presenting as concurrent oral and skin lesions, with the oral lesion
clinically resembling oral squamous cell carcinoma. Such lesions present a diagnostic
challenge, but the outcome is very favorable.
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Article info
Publication history
Published online: August 17, 2012
Accepted:
April 19,
2012
Received in revised form:
April 19,
2012
Received:
December 2,
2011
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
